Fas polyclonal antibody | Enzo Life Sciences ADI-AAP-221-F product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Fas polyclonal antibody

catalog :

ADI-AAP-221-F

quantity :

200 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

application :

western blot, immunohistochemistry

product information

Product ID :

ADI-AAP-221

Catalog Number :

ADI-AAP-221-F

Product Name :

Fas polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

200 µg

list of Pubmed id :

12810573

SPECIES REACTIVITY :

Human, Mouse, Rat

Background :

Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein with an apparent molecular weight of 44 kDa on SDS-PAGE. Fas belongs to the tumor necrosis factor receptor (TNFR) family, which includes TNFR1, TNFR2, CD27, CD30 and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells. Both Fas and TNFR contain a 70 amino acid cytoplasmic “death domain” responsible for transmitting signals for apoptosis. Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long forms of FLIP. Insertion of an early transposable element in intron 2 of the Fas gene, as in the mouse lpr mutations, causes lymphoproliferation and autoimmunity in mutant mice, suggesting the involvement of Fas in clonal deletion of autoreactive T cells.

ALTnames :

CD95, APO-1, TNFRSF 6

Immunogen :

Synthetic peptide corresponding to a portion of mouse Fas.

Buffer :

Liquid. In PBS, pH 7.2, containing 0.09% sodium azide.

Uses :

Detects a band of ~45kDa by Western blot.

Application Summary :

IHC, WB

Storage :

-20°C