Caspase-3 polyclonal antibody | Enzo Life Sciences ADI-AAP-113-F product information

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Caspase-3 polyclonal antibody

catalog :

ADI-AAP-113-F

quantity :

200 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat, dogs, chicken, bovine

application :

western blot, immunohistochemistry

more info or order :

Enzo Life Sciences product webpage

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1g	Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
western blot; human; loading ...; fig 1b	Wang C, Guo S, Wang J, Yan X, Farrelly M, Zhang Y, et al. Reactivation of ERK and Akt confers resistance of mutant BRAF colon cancer cells to the HSP90 inhibitor AUY922. Oncotarget. 2016;7:49597-49610 pubmed publisher
	Park E, Min K, Choi K, Kubatka P, Kruzliak P, Kim D, et al. Chloroquine enhances TRAIL-mediated apoptosis through up-regulation of DR5 by stabilization of mRNA and protein in cancer cells. Sci Rep. 2016;6:22921 pubmed publisher

product information

Product ID :

ADI-AAP-113

Catalog Number :

ADI-AAP-113-F

Product Name :

Caspase-3 polyclonal antibody

Host species :

Rabbit

Clonality :

Polyclonal

Product Type :

Antibody

Size :

200 µg

list of Pubmed id :

24201813, 23205553, 22929803, 21036719, 18326745, 12665479, 11980894, 11976344

SPECIES REACTIVITY :

Human, Mouse, Rat, Yeast, Rabbit, Porcine, Monkey, Hamster, Guinea pig, Dog, Chicken, Bovine

Background :

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

Immunogen :

Recombinant human Caspase-3 protein (full length).

Buffer :

Liquid. In PBS containing 50% glycerol and 0.09% sodium azide.

Uses :

Detects a band of ~36kDa by Western blot. A lower molecular weight band refers to a proteolytic cleavage product of caspase-3.

Application Summary :

IHC (PS), WB

Storage :

-20°C

more info or order :

Enzo Life Sciences product webpage