product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Fas monoclonal antibody (ZB4)
catalog :
ADI-AAM-227-E
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
ZB4
reactivity :
human
application :
western blot, flow cytometry, blocking or activating experiments
more info or order :
Enzo Life Sciences product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • blocking or activating experiments; human; fig 4
Difranco K, Johnson Farley N, Bertino J, Elson D, Vega B, Belinka B, et al. LFA-1-targeting Leukotoxin (LtxA; Leukothera®) causes lymphoma tumor regression in a humanized mouse model and requires caspase-8 and Fas to kill malignant lymphocytes. Leuk Res. 2015;39:649-56 pubmed publisher
Sagan D, Mörtl S, Muller I, Eckardt Schupp F, Eichholtz Wirth H. Enhanced CD95-mediated apoptosis contributes to radiation hypersensitivity of NBS lymphoblasts. Apoptosis. 2007;12:753-67 pubmed
product information
Product ID :
ADI-AAM-227
Catalog Number :
ADI-AAM-227-E
Product Name :
Fas monoclonal antibody (ZB4)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
25850729, 17219051
Clone :
ZB4
Isotype :
IgG1
SPECIES REACTIVITY :
Human
Background :
Fas/APO-1/CD95 is a 36 kDa cell surface type I-membrane glycoprotein that is a member of the Tumor necrosis factor receptor (TNF-R) family, which includes TNF-R1, TNF-R2, CD27, CD30, and CD40. Binding of Fas-ligand (FasL) to Fas or crosslinking of Fas by anti-Fas monoclonal antibodies leads to apoptosis of Fas expressing cells. Apoptosis induced by Fas-Fas ligand interaction is inhibited by a number of cytosolic factors such as the ICE/CED3 family inhibitor CrmA, and the short and long form of FLIP.
ALTnames :
CD95, APO-1, TNFRSF 6
Immunogen :
Recombinant human Fas.
Buffer :
Liquid. In PBS containing 50% glycerol.
Uses :
Detects a band of ~45kDa by Western blot. Functional Application: neutralizing.
Application Summary :
FC, WB, FUNC
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.