product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Caspase-7 monoclonal antibody (7-1-11)
catalog :
ADI-AAM-127-E
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7-1-11

The same clone is also sold as:
reactivity :
mouse
application :
western blot, immunohistochemistry, western blot knockout validation
more info or order :
Enzo Life Sciences product webpage
citations: 2
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; mouse; 1:1000
Cardona M, López J, Serafín A, Rongvaux A, Inserte J, García Dorado D, et al. Executioner Caspase-3 and 7 Deficiency Reduces Myocyte Number in the Developing Mouse Heart. PLoS ONE. 2015;10:e0131411 pubmed publisher
Kirsch D, Doseff A, Chau B, Lim D, de Souza Pinto N, Hansford R, et al. Caspase-3-dependent cleavage of Bcl-2 promotes release of cytochrome c. J Biol Chem. 1999;274:21155-61 pubmed
product information
Product ID :
ADI-AAM-127
Catalog Number :
ADI-AAM-127-E
Product Name :
Caspase-7 monoclonal antibody (7-1-11)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
10409669
Image Legend 4 :
IHC Analysis: Human placenta tissue stained with Caspase-7, mAb (7-1-11) at 10ug/ml.
Clone :
7-1-11
Isotype :
IgG2b
SPECIES REACTIVITY :
Human, Mouse, Rat, Sheep, Rabbit, Porcine, Monkey, Hamster, Dog
Background :
The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.
Immunogen :
Recombinant human Caspase-7 protein (full length) .
Specificity :
Detects the unprocessed pro-caspase-7 (p35), caspase lacking the short amino-terminal pro-domain (p32) and fully processed caspase-7 (p19) in the apototic cell extract.
Buffer :
Liquid. In PBS, pH 7.2, containing 0.1mM PMSF.
Uses :
Immunohistochemistry (paraffin sections). Western Blot (0.2µg/ml, ECL). Optimal conditions must be determined individually for each application.
Application Summary :
IHC (PS), WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.