IMMUNOSET® HSP27 high sensitivity (human), ELISA development set | Enzo Life Sciences ADI-960-076 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

IMMUNOSET® HSP27 high sensitivity (human), ELISA development set

catalog :

ADI-960-076

quantity :

5 x 96 wells

citations: 1

Reference
Kepenekian V, Aloy M, Magne N, Passot G, Armandy E, Decullier E, et al. Impact of hyperthermic intraperitoneal chemotherapy on Hsp27 protein expression in serum of patients with peritoneal carcinomatosis. Cell Stress Chaperones. 2013;18:623-30 pubmed publisher

product information

Product ID :

ADI-960-076

Catalog Number :

ADI-960-076

Product Name :

IMMUNOSET® HSP27 high sensitivity (human), ELISA development set

Product Type :

Kit

Size :

5 x 96 wells

list of Pubmed id :

23508575

Product Description :

The IMMUNOSET® HSP27 high sensitivity (human), EIA development set contains sufficient reagents for the development of 5 x 96 well EIA plates which provides analysis of ~200 samples in duplicate. Save time, money, and sample by developing your own EIA kits. Simply coat your plates and go! This kit provides superior accuracy with fully quantitative results compared to Western blot analysis and has low reactivity with related molecules.

SPECIES REACTIVITY :

Human

Background :

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes αB-crystallin. It is characterized by a conserved C-terminal α-crystallin domain consisting of two anti-parallel β-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-α, p70 S6K, PKD I, and PKC-δ. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

ALTnames :

Heat shock protein 27

Uses :

For the quantitative determination of human HSP27 in cell lysates, plasma, and serum.

Application Summary :

ELISA, Colorimetric detection

Storage :

+4°C