p53 (wild type) (human), (recombinant) | Enzo Life Sciences ADI-908-265-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

protein

product name :

p53 (wild type) (human), (recombinant)

catalog :

ADI-908-265-010

quantity :

10 µg

product information

Product ID :

ADI-908-265

Catalog Number :

ADI-908-265-010

Product Name :

p53 (wild type) (human), (recombinant)

Product Type :

Protein

Size :

10 µg

Background :

The p53 protein is a transcription factor that plays a crucial role as a tumor suppressor. In normal cells, p53 levels are kept low by degradation mediated by MDM2. In response to stress such as DNA damage and hypoxia, wild-type p53 activates genes that lead to cell cycle arrest and, in the event of severe stress, to apoptosis. The importance of p53 is illustrated by the presence of p53 mutants in 50% of all human cancers. When p53 is inactivated by either mutation or deletion, cells become increasingly vulnerable to malignant transformation. Mutations in p53 lead to a conformational change in protein structure which results in increased stability of the protein. Consequently, p53 is frequently found in higher levels in malignant cells than in normal cells.

ALTnames :

TRP53, Tumor protein p53

Purity :

≥90% (SDS-PAGE)

Buffer :

Liquid. In 50mM TRIS-Acetate, pH 7.5, containing 1mM EDTA 20% glycerol without BSA and sodium azide.

Uses :

Western blot control.

Application Summary :

ELISA, WB, Inhibition assay

Storage :

-80°C