Sonic hedgehog monoclonal antibody (10H6) | Enzo Life Sciences ADI-905-860-100 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Sonic hedgehog monoclonal antibody (10H6)

catalog :

ADI-905-860-100

quantity :

100 µl

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

10H6

reactivity :

human

application :

western blot

product information

Product ID :

ADI-905-860

Catalog Number :

ADI-905-860-100

Product Name :

Sonic hedgehog monoclonal antibody (10H6)

Host species :

Mouse

Clonality :

Monoclonal

Product Type :

Antibody

Size :

100 µl

Clone :

10H6

Isotype :

IgG1

SPECIES REACTIVITY :

Human

Background :

Sonic Hedgehog (SHH) is instrumental in patterning the early embryo. It has been implicated as the key inductive signal in patterning of the ventral neural tube, the anterior-posterior limb axis, and the ventral somites. Of three human proteins showing sequence and functional similarity to the sonic hedgehog protein of Drosophila, this protein is the most similar. The protein is made as a precursor that is autocatalytically cleaved; the N-terminal portion is soluble and contains the signalling activity while the C-terminal portion is involved in precursor processing. More importantly, the C-terminal product covalently attaches a cholesterol moiety to the N-terminal product, restricting the N-terminal product to the cell surface and preventing it from freely diffusing throughout the developing embryo.

ALTnames :

SHH

Immunogen :

Recombinant human SHH (sonic hedgehog) (aa 24-197).

Buffer :

Liquid. In PBS, pH 7.3, containing 1% BSA, 50% glycerol and 0.02% sodium azide.

Uses :

Detects a band of ~50kDa (full length) by Western blot.

Application Summary :

Storage :

-20°C