Angiotensin II receptor AT1 polyclonal antibody (DY-682 conjugate) | Enzo Life Sciences ADI-905-813-100 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

antibody

product name :

Angiotensin II receptor AT1 polyclonal antibody (DY-682 conjugate)

catalog :

ADI-905-813-100

quantity :

100 µg

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry

product information

Product ID :

ADI-905-813

Catalog Number :

ADI-905-813-100

Product Name :

Angiotensin II receptor AT1 polyclonal antibody (DY-682 conjugate)

Host species :

Rabbit

Clonality :

Polyclonal

Conjugation :

DY-682

Product Type :

Antibody

Size :

100 µg

SPECIES REACTIVITY :

Human, Mouse, Rat

Background :

The octapeptide circulatory hormone Angiotensin II is a critical regulator of cardiovascular homeostasis formed in blood, with dual function in tissues of the brain, kidney, heart, and vasculature as an autocrine/paracrine growth hormone. The actions of angiotensin II are mediated by type one (AT1) and type two (AT2) angiotensin II receptors, members of the seven-transmembrane Gprotein coupled receptor (GPCR) family. AT1 receptors couple predominantly with Gq/11 alpha subunits, and signal through phospholipases C, D, and A2, inositol phosphates, and calcium channels, as well as a variety of serine/threonine and tyrosine kinases. AT1 expression is greatest in vascular smooth muscle, liver, kidney, adrenal cortex, brain, and lung, and is primarily responsible for the physiological effects of angiotensin II, including regulation of arterial blood pressure, electrolyte and water balance, thirst, hormone secretion, and renal function. The AT2 receptor displays approximately 30% identity to the AT1 receptor, and is highly expressed during embryonic development. AT2 expression in adult tissue is limited to the adrenal medulla, brain, and reproductive tissues, but is upregulated in injured tissue following myocardial infarction, vascular injury, and wound healing. AT2 receptor signaling is not dependent on G-protein coupling or receptor phosphorylation, although coupling to Gia2 and Gia3 alpha subunits occurs in some tissues. AT2 activation can stimulate tyrosine and serine/threonine phosphatases through activation of nitric oxide and cGMP, and appears to counteract the stimulatory effects of AT1 receptor and growth factor receptor signaling.

ALTnames :

AGTR1

Immunogen :

Synthetic peptide corresponding to the sequence near the N-terminus of rat angiotensin II receptor AT1.

Buffer :

Liquid. In PBS containing 50% glycerol and 0.01% sodium azide.

Uses :

Suitable for membrane-based ELISA. Predicted MW of ~41kDa. Higher MW species (~55kDa) and intermediates also observed by Western blot which reflect post-translational modification and dimerization of the receptor.

Application Summary :

ELISA, IHC, WB

Storage :

-20°C