This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
SOCS1 polyclonal antibody
catalog :
ADI-905-732-100
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot
product information
Product ID :
ADI-905-732
Catalog Number :
ADI-905-732-100
Product Name :
SOCS1 polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Product Type :
Antibody
Size :
100 µg
SPECIES REACTIVITY :
Human, Mouse, Rat
Background :
The suppressor of cytokine signaling (SOCS) and cytokine-inducible SH2 proteins are a family of intracellular proteins that regulate the cellular immune response to cytokines. SOCS1 acts to suppress dendritic cell (DC) and T cell hyperactivation in response to cytokine signaling by inhibiting the JAK tyrosine kinase. JAK tyrosine kinase activity is necessary for type I and II cytokine receptors to initiate signaling, and its activity is blocked by direct binding of SOCS1 to the catalytic domain of the kinase. SOCS1 also possesses E3 ubiquitin protein ligase activity that results in the polyubiquitination of its target proteins and subsequent degradation by the proteosome. It is through this method that SOCS1 negatively regulates signaling by Toll-like receptors TLR2 and TLR4 by mediating the degradation of the TLR signaling adaptor protein TIRAP.
ALTnames :
Suppressor of cytokine signaling 1
Immunogen :
Synthetic peptide corresponding to the sequence near the C-terminus of human SOCS1.
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Uses :
Detects a band of ~39kDa by Western blot.
Application Summary :
WB
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.