This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
IRE1p polyclonal antibody
catalog :
ADI-905-727-100
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunocytochemistry
product information
Product ID :
ADI-905-727
Catalog Number :
ADI-905-727-100
Product Name :
IRE1p polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Product Type :
Antibody
Size :
100 µg
SPECIES REACTIVITY :
Human, Mouse, Rat
Background :
Accumulation of misfolded proteins in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR) and upregulation of the ER molecular chaperones GRP78 and GRP94. These proteins are normally bound to ER transmembrane proteins such as IRE1p and ATF6 but ER stress induces their dissociation. This allows IRE1p, a serine-threonine protein kinase, to transduce the unfolded protein signal from the ER to the nucleus. IRE1p also functions as an endoribonuclease to splice X-box binding protein (XBP1) mRNA, converting it to a potent UPR transcriptional activator.
Immunogen :
Synthetic peptide corresponding to the sequence near the C-terminus of human IRE1p.
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Uses :
Detects a band of ~110kDa by Western blot.
Application Summary :
ICC, WB
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.