product summary
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company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
Osteopontin monoclonal antibody (53)
catalog :
ADI-905-629-100
quantity :
100 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
53
reactivity :
human
application :
western blot, ELISA, immunohistochemistry
more info or order :
Enzo Life Sciences product webpage
citations: 1
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:2,000
Mutrie J, Chambers A, Tuck A. Osteopontin increases breast cancer cell sensitivity to specific signaling pathway inhibitors in preclinical models. Cancer Biol Ther. 2011;12:680-90 pubmed publisher
product information
Product ID :
ADI-905-629
Catalog Number :
ADI-905-629-100
Product Name :
Osteopontin monoclonal antibody (53)
Host species :
Mouse
Clonality :
Monoclonal
Product Type :
Antibody
Size :
100 µg
Clone :
53
Isotype :
IgG2a
SPECIES REACTIVITY :
Human
Background :
Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.
ALTnames :
OPN, SPP1, Secreted phosphoprotein 1, Bone sialoprotein 1
Immunogen :
Recombinant human Osteopontin.
Buffer :
Liquid. In PBS containing 0.1% sodium azide.
Application Summary :
ELISA, IHC (FS), IHC (PS), WB
Storage :
-20°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.