product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
antibody
product name :
ASC polyclonal antibody
catalog :
ADI-905-173-100
quantity :
100 µg
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse
application :
western blot, immunocytochemistry, immunohistochemistry - paraffin section, proximity ligation assay
more info or order :
Enzo Life Sciences product webpage
citations: 5
Published Application/Species/Sample/DilutionReference
  • proximity ligation assay; mouse; loading ...; fig s10a
Li X, Thome S, Ma X, Amrute Nayak M, Finigan A, Kitt L, et al. MARK4 regulates NLRP3 positioning and inflammasome activation through a microtubule-dependent mechanism. Nat Commun. 2017;8:15986 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; fig 2
Paramel Varghese G, Folkersen L, Strawbridge R, Halvorsen B, Yndestad A, Ranheim T, et al. NLRP3 Inflammasome Expression and Activation in Human Atherosclerosis. J Am Heart Assoc. 2016;5: pubmed publisher
  • western blot; human; loading ...; fig 4A
Yang Z, Cao J, Yu C, Yang Q, Zhang Y, Han L. Caspase-1 mediated interleukin-18 activation in neutrophils promotes the activity of rheumatoid arthritis in a NLRP3 inflammasome independent manner. Joint Bone Spine. 2016;83:282-9 pubmed publisher
Spadaro O, Goldberg E, Camell C, Youm Y, Kopchick J, Nguyen K, et al. Growth Hormone Receptor Deficiency Protects against Age-Related NLRP3 Inflammasome Activation and Immune Senescence. Cell Rep. 2016;14:1571-1580 pubmed publisher
Aflaki E, Moaven N, Borger D, Lopez G, Westbroek W, Chae J, et al. Lysosomal storage and impaired autophagy lead to inflammasome activation in Gaucher macrophages. Aging Cell. 2016;15:77-88 pubmed publisher
product information
Product ID :
ADI-905-173
Catalog Number :
ADI-905-173-100
Product Name :
ASC polyclonal antibody
Host species :
Rabbit
Clonality :
Polyclonal
Product Type :
Antibody
Size :
100 µg
list of Pubmed id :
26486234, 26123077, 26069969, 26045078, 26006022, 25973362, 25867480, 25686106, 25686105, 23066025
SPECIES REACTIVITY :
Human
Background :
ASC (Apoptosis-associated speck-like protein containing a CARD domain) is a bipartite protein comprising two protein-protein interaction domains, a Pyrin domain (PYD) and a caspase recruitment domain (CARD). Proteins containing these domains play pivotal roles in regulating apoptosis and immune response pathways. Reported functions of ASC include apoptosis, activation of inflammatory caspases and regulation of NFκB.
ALTnames :
Apoptosis-associated speck-like protein containing a CARD, Caspase recruitment domain-containing protein 5, CARD-5, PYD and CARD domain-containing protein, PYCARD, Target of methylation-induced silencing, TMS1
Immunogen :
Synthetic peptide corresponding to aa 182-195 of human ASC .
Buffer :
Liquid. In PBS containing 0.02% sodium azide.
Uses :
Detects a band of ~25kDa by Western blot.
Application Summary :
ICC, WB
Storage :
+4°C
more info or order :
Enzo Life Sciences product webpage
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.