Aldosterone ELISA kit | Enzo Life Sciences ADI-901-173 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Aldosterone ELISA kit

catalog :

ADI-901-173

quantity :

5 x 96 wells

citations: 9

Reference
Zhang Y, Peti Peterdi J, Heiney K, Riquier Brison A, Carlson N, MÃ¼ller C, et al. Clopidogrel attenuates lithium-induced alterations in renal water and sodium channels/transporters in mice. Purinergic Signal. 2015;11:507-18 pubmed publisher
Hathaway C, Gasim A, Grant R, Chang A, Kim H, Madden V, et al. Low TGFÎ²1 expression prevents and high expression exacerbates diabetic nephropathy in mice. Proc Natl Acad Sci U S A. 2015;112:5815-20 pubmed publisher
Wang X, Huang C, Zhao Q, Huang H, Tang Y, Dai Z, et al. Effect of renal sympathetic denervation on the progression of paroxysmal atrial fibrillation in canines with long-term intermittent atrial pacing. Europace. 2015;17:647-54 pubmed publisher
Qiao Y, He W, Chen C, Zhang C, Zhao W, Wang P, et al. Myosin phosphatase target subunit 1 (MYPT1) regulates the contraction and relaxation of vascular smooth muscle and maintains blood pressure. J Biol Chem. 2014;289:22512-23 pubmed publisher
Dhar I, Dhar A, Wu L, Desai K. Methylglyoxal, a reactive glucose metabolite, increases renin angiotensin aldosterone and blood pressure in male Sprague-Dawley rats. Am J Hypertens. 2014;27:308-16 pubmed publisher
Conway V, Couture P, Gauthier S, Pouliot Y, Lamarche B. Effect of buttermilk consumption on blood pressure in moderately hypercholesterolemic men and women. Nutrition. 2014;30:116-9 pubmed publisher
Katayama T, Sueta D, Kataoka K, Hasegawa Y, Koibuchi N, Toyama K, et al. Long-term renal denervation normalizes disrupted blood pressure circadian rhythm and ameliorates cardiovascular injury in a rat model of metabolic syndrome. J Am Heart Assoc. 2013;2:e000197 pubmed publisher
Mittag J, Lyons D, Sällström J, Vujovic M, Dudazy Gralla S, Warner A, et al. Thyroid hormone is required for hypothalamic neurons regulating cardiovascular functions. J Clin Invest. 2013;123:509-16 pubmed publisher
Singh S, O HARA B, Talukder J, Rajendran V. Aldosterone induces active K? secretion by enhancing mucosal expression of Kcnn4c and Kcnma1 channels in rat distal colon. Am J Physiol Cell Physiol. 2012;302:C1353-60 pubmed publisher

product information

Product ID :

ADI-901-173

Catalog Number :

ADI-901-173

Product Name :

Aldosterone ELISA kit

Product Type :

Kit

Size :

5 x 96 wells

list of Pubmed id :

26386699, 25902541, 25349225, 24951589, 24436324, 24206823, 23974905, 23257356, 22322970

Product Description :

The Aldosterone EIA kit is a colorimetric competitive enzyme immunoassay kit with results overnight + 1 hour.

SPECIES REACTIVITY :

Species independent

Background :

Aldosterone is a steroid hormone synthesized from cholesterol in the adrenal cortex. Aldosterone is metabolized in the kidney and liver, and functions as the key mineralocorticoid in the control of sodium and potassium balance. Synthesis and release of aldosterone by the adrenal gland is primarily regulated by the renin-angiotensin-aldosterone system (RAAS), the main regulatory system involved in blood pressure regulation, renal hemodynamics, and sodium-volume homeostasis. Measurement of serum aldosterone in conjunction with plasma renin is used clinically to differentiate between primary and secondary aldosteronism. Primary aldosteronism (hyperaldosteronism) is characterized by a very low renin:aldosterone ratio leading to the retention of sodium and increased blood pressure, and is typically the result of renal gland hyperplasia or tumors. In secondary aldosteronism, hyperproduction of aldosterone results from external conditions such as heart failure and renal artery disease that reduce renal blood flow and stimulate the RAAS mechanism. The RAAS directly affects vascular and cardiac remodeling through proliferative and inflammatory signaling, as aldosterone and salt have been shown to increase the expression of intracellular cyclooxygenase-2, osteopontin, and MCP-1 in rats. Aldosterone acts by binding to the mineralocorticoid receptor (MR) triggering the transcription of hormone responsive genes, and clinical studies have shown that patients with congestive heart failure or after myocardial infarction benefited from MR antagonist treatment. As pharmacological modulation of nuclear hormone receptors is a common strategy for the treatment of cardiovascular disease, determining the effect of such treatments on the RAAS is of increasing value in evaluating the safety and efficacy of new targeted therapeutics.

Uses :

For the quantitative determination of Aldosterone in plasma, serum, and urine from any species.

Application Summary :

ELISA, Colorimetric detection