8-iso-PGF2α ELISA kit | Enzo Life Sciences ADI-901-010 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

8-iso-PGF2α ELISA kit

catalog :

ADI-901-010

quantity :

5 x 96 wells

citations: 2

Reference
Williams D, Wan Z, Frier B, Bell R, Field C, Wright D. Dietary supplementation with vitamin E and C attenuates dexamethasone-induced glucose intolerance in rats. Am J Physiol Regul Integr Comp Physiol. 2012;302:R49-58 pubmed publisher
Dimopoulos N, Piperi C, Psarra V, Lea R, Kalofoutis A. Increased plasma levels of 8-iso-PGF2alpha and IL-6 in an elderly population with depression. Psychiatry Res. 2008;161:59-66 pubmed publisher

product information

Product ID :

ADI-901-010

Catalog Number :

ADI-901-010

Product Name :

8-iso-PGF2α ELISA kit

Product Type :

Kit

Size :

5 x 96 wells

list of Pubmed id :

22031784, 18783834

Product Description :

The measurement of F2-isoprostanes has emerged as one of the most reliable approaches to assess oxidative stress status in vivo, providing an important tool to explore the role of oxidative stress in the pathogenesis of human disease. This is a colorimetric competitive immunoassay kit for the quantitative determination of free 8-iso-Prostaglandin F2α in biological fluids such as urine and in culture supernatants. To measure 8-iso-Prostaglandin F2α levels in serum, plasma or other tissue samples, use the Direct 8-iso-PGF2α EIA Kit. 8-iso-PGF2α is produced in vivo by both non-cyclooxygenase and cyclooxygenase dependant mechanisms from arachidonic acid. It has been shown to be a potent vasoconstrictor, a potential mediator of hepatorenal syndrome and a mutagen in 3T3 cells and vascular smooth muscle cells. 8-iso-PGF2α has been shown to circulate in plasma and is excreted in urine.

SPECIES REACTIVITY :

Species independent

Background :

Prostaglandin F2α (PGF2α) is formed in a variety of cells from PGH2, which itself is synthesized from arachidonic acid by the enzyme prostaglandin synthetase. PGF2α is often viewed as an antagonist to PGE2 due to their opposing effects on various tissues. PGF2α is a potent bronchoconstrictor and has been implicated in asthma attacks. PGF2α is also involved in reproductive functions including corpus luteum regulation, uterine contractions, and sperm motility. This has led to its use in terminating pregnancies and inducing labor at term. High levels of PGF2α have also been associated with preeclampsia.

ALTnames :

8-iso-Prostaglandin F2α

Uses :

For the quantitative determination of 8-iso-PGF2α in culture supernatants, tissue, and urine from any species. Cited sample types include plasma.

Application Summary :

ELISA, Colorimetric detection

Storage :

+4°C