KIM-1 (human) ELISA kit | Enzo Life Sciences ADI-900-226-0001 product information

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product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

KIM-1 (human) ELISA kit

catalog :

ADI-900-226-0001

quantity :

96 wells

citations: 5

Reference
Du Y, Hou L, Guo J, Sun T, Wang X, Wu Y. Renal neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 expression in children with acute kidney injury and Henoch-Schönlein purpura nephritis. Exp Ther Med. 2014;7:1130-1134 pubmed
Urbschat A, Gauer S, Paulus P, Reissig M, Weipert C, Ramos Lopez E, et al. Serum and urinary NGAL but not KIM-1 raises in human postrenal AKI. Eur J Clin Invest. 2014;44:652-9 pubmed publisher
Kim S, Song S, Kim I, Kim W, Jeon Y, Kim B, et al. Nonalbuminuric proteinuria as a biomarker for tubular damage in early development of nephropathy with type 2 diabetic patients. Diabetes Metab Res Rev. 2014;30:736-41 pubmed publisher
Nozaki Y, Kinoshita K, Yano T, Shiga T, Hino S, Niki K, et al. Estimation of kidney injury molecule-1 (Kim-1) in patients with lupus nephritis. Lupus. 2014;23:769-77 pubmed publisher
Holzscheiter L, Beck C, Rutz S, Manuilova E, Domke I, Guder W, et al. NGAL, L-FABP, and KIM-1 in comparison to established markers of renal dysfunction. Clin Chem Lab Med. 2014;52:537-46 pubmed publisher

product information

Product ID :

ADI-900-226

Catalog Number :

ADI-900-226-0001

Product Name :

KIM-1 (human) ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

24940398, 24837251 , 24687388, 24598218 , 24243749

Product Description :

The KIM-1 (human) ELISA kit is a complete, colorimetric, immunometric immunoassay kit for the quantitative determination of human KIM-1 in urine with results in <2 hours.

SPECIES REACTIVITY :

Human

Background :

Chronic kidney disease (CKD) is a major public health problem, as one in nine American adults have CKD. There have been numerous studies focused on this disease over the years but there remains a need for improved therapeutics and identifying and/or predicting patient outcomes. One protein that has been identified as playing an important role in kidney disease is Kidney Injury Molecule-1 (KIM-1). KIM-1 is a 30KDa, type 1 membrane protein with an ectodomain that contains immunoglobulin and highly O-glycosylated mucin subdomains as well as multiple N-glycosylation sites. It is the most highly upregulated protein in the proximal tubule of the injured kidney. It exists in very low levels in normal kidneys but when upregulated during injury, it is detectable in urine in a wide variety of human diseases. KIM-1 is a potential biomarker for renal injury, which would suggest it has great importance in various kidney diseases and disorders, such as chronic kidney disease (as mentioned above), as well as acute tubular necrosis and acute kidney failure.

ALTnames :

Kidney injury molecule-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIMD-1, TIM-1, HAVCR1, Hepatitis A virus cellular receptor 1

Uses :

For the quantitative determination of human KIM-1 in urine.

Application Summary :

ELISA, Colorimetric detection

Storage :

+4°C