SMN ELISA kit | Enzo Life Sciences ADI-900-209 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

SMN ELISA kit

catalog :

ADI-900-209

quantity :

96 wells

citations: 4

Reference
Bogdanik L, Osborne M, Davis C, Martin W, Austin A, Rigo F, et al. Systemic, postsymptomatic antisense oligonucleotide rescues motor unit maturation delay in a new mouse model for type II/III spinal muscular atrophy. Proc Natl Acad Sci U S A. 2015;112:E5863-72 pubmed publisher
Kobayashi D, DECKER D, Zaworski P, Klott K, McGonigal J, Ghazal N, et al. Evaluation of peripheral blood mononuclear cell processing and analysis for Survival Motor Neuron protein. PLoS ONE. 2012;7:e50763 pubmed publisher
Schreml J, Riessland M, Paterno M, Garbes L, Roßbach K, Ackermann B, et al. Severe SMA mice show organ impairment that cannot be rescued by therapy with the HDACi JNJ-26481585. Eur J Hum Genet. 2013;21:643-52 pubmed publisher
Kobayashi D, Olson R, Sly L, Swanson C, Chung B, Naryshkin N, et al. Utility of survival motor neuron ELISA for spinal muscular atrophy clinical and preclinical analyses. PLoS ONE. 2011;6:e24269 pubmed publisher

product information

Product ID :

ADI-900-209

Catalog Number :

ADI-900-209

Product Name :

SMN ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

26460027, 23226377, 23073311, 21904622

Product Description :

The SMN EIA kit is a colorimetric immunometric immunoassay kit with results in 3 hours.

SPECIES REACTIVITY :

Human, Mouse

Background :

Survival Motor Neuron (SMN) is a ~38 kDa protein produced chiefly by the SMN1 gene, located on the telomeric portion of chromosome 5q. A nearly identical centromeric copy of the gene (SMN2) also produces a small amount of full-length SMN protein, but due to a translationally silent C-T transition that results in alternative splicing of the pre-mRNA, most of the resulting SMN is truncated, causing reduced protein stability and lower overall SMN levels. Deletion or mutation of the SMN1 gene results in a reduced level of full-length SMN protein and manifests as a range of neuromuscular phenotypes in humans as the disease spinal muscular atrophy (SMA). SMA is characterized by muscle weakness and atrophy, functional disability and is the most common lethal genetic disease of infants and toddlers. Approximately one in 35 adults is a carrier of the SMN1 mutation. The incidence of SMA is 1 in 6,000 to 1 in 10,000 live births. SMN protein is present in the cell cytoplasm, and also in the nucleus where it is concentrated in “gem” structures associated with Cajal bodies. SMN protein is a constituent of Gemin-containing complexes, and is thought to participate in many aspects of RNA metabolism. SMN complexes have been shown to mediate the assembly of uridine rich small nuclear ribonucleoproteins (snRNPs), which in turn act as critical components of spliceosomes.

ALTnames :

Survival motor neuron

Uses :

For the quantitative determination of human and mouse SMN in cell lysate samples.

Application Summary :

ELISA, Colorimetric detection

Storage :

-20°C