[pSer78]HSP27 (human), ELISA kit | Enzo Life Sciences ADI-900-165 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

[pSer78]HSP27 (human), ELISA kit

catalog :

ADI-900-165

quantity :

96 wells

citations: 1

Reference
Tokuda H, Kuroyanagi G, Tsujimoto M, Enomoto Y, Matsushima Nishiwaki R, Onuma T, et al. Release of Phosphorylated HSP27 (HSPB1) from Platelets Is Accompanied with the Acceleration of Aggregation in Diabetic Patients. PLoS ONE. 2015;10:e0128977 pubmed publisher

product information

Product ID :

ADI-900-165

Catalog Number :

ADI-900-165

Product Name :

[pSer78]HSP27 (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

26046355

Product Description :

The [pSer78]HSP27 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours.

SPECIES REACTIVITY :

Human

Background :

Hsp27 is one of the most common members of the highly conserved and ubiquitously expressed family of small heat shock proteins (sHsp), which also includes αB-crystallin. It is characterized by a conserved C-terminal alpha-crystallin domain consisting of two anti-parallel beta-sheets that promote oligomer formation required for its primary chaperone function as inhibitor of irreversible protein aggregation. Hsp27 oligomerization is modulated by post-translational phosphorylation of Hsp27 at three serine residues, Ser15, Ser78, and Ser82, by a variety of protein kinases including MAPKAPK-3, PKAc-α, p70 S6K, PKD I, and PKC-δ;. Hsp27 has been shown to inhibit actin polymerization by binding of unphosphorylated Hsp27 monomers to actin intermediate filaments. Anti-apoptotic functions of Hsp27 have also been identified through interactions with DAXX7, activation of Akt, and inhibition of apoptosome formation. Evidence suggests altered expression of Hsp27 is implicated in the pathogenesis of breast, ovarian, and prostate cancer.

ALTnames :

Heat shock protein 27

Uses :

For the quantitative determination of human [pSer78]HSP27 in cell lysates, plasma, and serum.

Application Summary :

ELISA, Colorimetric detection