Dkk-1 (human), ELISA kit | Enzo Life Sciences ADI-900-151 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Dkk-1 (human), ELISA kit

catalog :

ADI-900-151

quantity :

96 wells

citations: 3

Reference
Soydinc H, Duranyildiz D, Camlica H, Oral E, Yasasever V. Lack of diagnostic potential of Dickkopf-1 in colon and rectum cancers. Asian Pac J Cancer Prev. 2011;12:3187-9 pubmed
Delforge M, Terpos E, Richardson P, Shpilberg O, Khuageva N, Schlag R, et al. Fewer bone disease events, improvement in bone remodeling, and evidence of bone healing with bortezomib plus melphalan-prednisone vs. melphalan-prednisone in the phase III VISTA trial in multiple myeloma. Eur J Haematol. 2011;86:372-84 pubmed publisher
Betts A, Clark T, Yang J, Treadway J, Li M, Giovanelli M, et al. The application of target information and preclinical pharmacokinetic/pharmacodynamic modeling in predicting clinical doses of a Dickkopf-1 antibody for osteoporosis. J Pharmacol Exp Ther. 2010;333:2-13 pubmed publisher

product information

Product ID :

ADI-900-151

Catalog Number :

ADI-900-151

Product Name :

Dkk-1 (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

22471451, 21366694, 20089807

Product Description :

The Dkk-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours. Absorbance is read at 450 nm. The Dkk-1 (human), EIA kit offers ultra-sensitive and accurate measurement of Dickkopf-1 and has been validated in-house in normal and pathological samples.

SPECIES REACTIVITY :

Human

Background :

Dkk-1 (Dickkopf-1) is a secreted inhibitor of the canonical Wnt signaling pathway, which mediates a variety of cellular processes including the growth and development of osteoblasts. Dkk-1 disrupts the canonical pathway by binding to the LRP5/6 co-receptors, preventing interaction with Wnt, and facilitating the degradation of beta-catenin. Dkk-1 is overexpressed in multiple myeloma, increasing bone resorption and the appearance of osteolytic lesions characteristic of multiple myeloma.

ALTnames :

Dickkopf-1

Uses :

For the quantitative determination of human Dkk-1 in culture supernatants, plasma, and serum.

Application Summary :

ELISA, Colorimetric detection