Osteopontin (human), ELISA kit | Enzo Life Sciences ADI-900-142 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Osteopontin (human), ELISA kit

catalog :

ADI-900-142

quantity :

96 wells

citations: 6

Reference
Anborgh P, Caria L, Chambers A, Tuck A, Stitt L, Brackstone M. Role of plasma osteopontin as a biomarker in locally advanced breast cancer. Am J Transl Res. 2015;7:723-32 pubmed
Bramwell V, Tuck A, Chapman J, Anborgh P, Postenka C, Al Katib W, et al. Assessment of osteopontin in early breast cancer: correlative study in a randomised clinical trial. Breast Cancer Res. 2014;16:R8 pubmed publisher
Francia P, Adduci C, Semprini L, Borro M, Ricotta A, Sensini I, et al. Osteopontin and galectin-3 predict the risk of ventricular tachycardia and fibrillation in heart failure patients with implantable defibrillators. J Cardiovasc Electrophysiol. 2014;25:609-16 pubmed publisher
Kivisakk P, Healy B, Francois K, Gandhi R, Gholipour T, Egorova S, et al. Evaluation of circulating osteopontin levels in an unselected cohort of patients with multiple sclerosis: relevance for biomarker development. Mult Scler. 2014;20:438-44 pubmed publisher
Karadag F, Gulen S, Karul A, Kilicarslan N, Ceylan E, Kuman N, et al. Osteopontin as a marker of weight loss in lung cancer. Scand J Clin Lab Invest. 2011;71:690-4 pubmed publisher
Tang C, Huang T, Chang C, Fu W, Yang R. Water solution of onion crude powder inhibits RANKL-induced osteoclastogenesis through ERK, p38 and NF-kappaB pathways. Osteoporos Int. 2009;20:93-103 pubmed publisher

product information

Product ID :

ADI-900-142

Catalog Number :

ADI-900-142

Product Name :

Osteopontin (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

26064440, 24451146, 24400815, 24005026, 22017168, 18506384

Product Description :

The Osteopontin (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours. Absorbance is read at 450 nm. Ready-to-use liquid color-coded reagents reduce error. Excellent publications in peer-reviewed publications demonstrate the utility and consistency of this kit developed with highly cited double monoclonal antibodies.

SPECIES REACTIVITY :

Human

Background :

Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to be a positive indicator of colon and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

ALTnames :

OPN, SPP1, Secreted phosphoprotein 1, Bone sialoprotein 1

Uses :

For the quantitative determination of human Osteopontin in culture supernatants, milk, plasma, and urine. Cited sample type includes serum.

Application Summary :

ELISA, Colorimetric detection