Bcl-2 (human), ELISA kit | Enzo Life Sciences ADI-900-133 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Bcl-2 (human), ELISA kit

catalog :

ADI-900-133

quantity :

96 wells

citations: 5

Reference
He X, Zhang T. Alteration in the balance of prosurvival and proapoptotic signalling pathways leads to sequence-dependent synergism between docetaxel and sorafenib in human non-small cell lung cancer cell lines. Cell Biochem Biophys. 2014;68:411-8 pubmed publisher
Hyun J, Grova M, Nejadnik H, Lo D, Morrison S, Montoro D, et al. Enhancing in vivo survival of adipose-derived stromal cells through Bcl-2 overexpression using a minicircle vector. Stem Cells Transl Med. 2013;2:690-702 pubmed publisher
Chitchumroonchokchai C, Thomas Ahner J, Li J, Riedl K, Nontakham J, Suksumrarn S, et al. Anti-tumorigenicity of dietary ?-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase II metabolites. Mol Nutr Food Res. 2013;57:203-11 pubmed publisher
Bae K, Lee J, Lee S, Park T, Nam Y. Optically traceable solid lipid nanoparticles loaded with siRNA and paclitaxel for synergistic chemotherapy with in situ imaging. Adv Healthc Mater. 2013;2:576-84 pubmed publisher
Plaschke K, Bergmann M, Kopitz J. Ginkgo extract EGb 761(®) shields from slowly accumulating neurodegenerative-like changes in a newly developed cell culture model induced by the combined action of low doses of antimycin A1 and 2-deoxy-D-glucose. J Neural Transm (Vienna). 2011;118:1247-54 pubmed publisher

product information

Product ID :

ADI-900-133

Catalog Number :

ADI-900-133

Product Name :

Bcl-2 (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

23990130, 23934910, 23239542, 23184673, 21479515

Product Description :

The Bcl-2 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours that measures pan Bcl-2. Absorbance is read at 450 nm. Obtain results from up to 39 samples in duplicate per 96-well kit. The Bcl-2 (human), EIA kit provides fully quantitative results that surpass semi-quantitative Western blot analysis and easy-to-use liquid color-coded reagents that reduce error.

SPECIES REACTIVITY :

Human

Background :

Bcl-2 (B-cell lymphoma 2) is an oncogenic protein that inhibits apoptosis. It is located within the mitochondrial membrane, endoplasmic reticulum and nuclear envelope. Bcl-2 is encoded by a 230kb gene that results in a 24-26kDa protein4. Bakhshi first identified Bcl-2 as an apoptotic proto-oncogene while studying chromosomal translocations in human follicular lymphomas. At approximately the same time Tsujimoto and Croce made the same observation. The function of Bcl-2 was first described by Vaux when it was demonstrated that it promoted the survival of factor dependent cells. Bcl-2 overexpression has been implicated in a wide variety of malignancies including (but not limited to) breast, prostate, skin, colon and pancreatic cancers. Related anti-apoptotic proteins include Bcl-xL, Mcl-1 and Bcl-w. Pro-apoptotic proteins in the Bcl-2 family include Bax, BAD, Bak, Blk and Bid.

Uses :

For the quantitative determination of Bcl-2 in cell lysates of human origin.

Application Summary :

ELISA, Colorimetric detection