Survivin (human), ELISA kit | Enzo Life Sciences ADI-900-111 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Survivin (human), ELISA kit

catalog :

ADI-900-111

quantity :

96 wells

citations: 4

Reference
Stoetzer O, Fersching D, Salat C, Steinkohl O, Gabka C, Hamann U, et al. Prediction of response to neoadjuvant chemotherapy in breast cancer patients by circulating apoptotic biomarkers nucleosomes, DNAse, cytokeratin-18 fragments and survivin. Cancer Lett. 2013;336:140-8 pubmed publisher
Singh R, Tyagi A, Sharma G, Mohan S, Agarwal R. Oral silibinin inhibits in vivo human bladder tumor xenograft growth involving down-regulation of survivin. Clin Cancer Res. 2008;14:300-8 pubmed publisher
Goksel G, Taneli F, Uslu R, Ulman C, Dinc G, Coskun T, et al. Serum her-2/neu and survivin levels and their relationship to histological parameters in early-stage breast cancer. J Int Med Res. 2007;35:165-72 pubmed
Ferrario A, Rucker N, Wong S, Luna M, Gomer C. Survivin, a member of the inhibitor of apoptosis family, is induced by photodynamic therapy and is a target for improving treatment response. Cancer Res. 2007;67:4989-95 pubmed

product information

Product ID :

ADI-900-111

Catalog Number :

ADI-900-111

Product Name :

Survivin (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

18172282, 17542404, 17510430

Product Description :

The Survivin (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours. Absorbance is read at 450 nm. This is the first Survivin (human), EIA kit commercially available and has been cited in numerous peer-reviewed publications.

SPECIES REACTIVITY :

Human

Background :

Survivin is a 16.5 kDa protein and the smallest inhibitor of apoptosis (IAP) so far identified. It is involved in the inhibition of apoptosis and cell division. Survivin expression has been reported at high levels in embryonic tissues, but at low or non-detectable levels in normal tissue. Survivin regulates the G2/M phase of the cell cycle by associating with the mitotic spindle microtubules and directly inhibits Caspase-3 and Caspase-7. Survivin is selectively expressed in the most common human cancers and is associated with clinical tumor progression. It has been proposed as a tumor marker for breast cancer, and Survivin expression has been correlated to clinical outcome in melanoma patients. Down-regulation or loss of Survivin is thought to inhibit the growth of tumor cells. Further, it has been indicated that Survivin epitopes may serve as important targets for anticancer immunotherapy approaches, and that Survivin is a rational target for apoptosis-based cancer therapy. It has also been proposed that Survivin may be used as a universal tumor antigen for immunotherapy.

ALTnames :

TIAP

Uses :

For the quantitative determination of human Survivin in cell lysates, culture supernatants, plasma, serum, and urine.

Application Summary :

ELISA, Colorimetric detection

Storage :

+4°C