This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Enzo Life Sciences
other brands :
Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis
product type :
ELISA/assay
product name :
Leptin (human), ELISA kit
catalog :
ADI-900-028A
quantity :
96 wells
citations: 9
Reference
Chavarria Avila E, Vázquez Del Mercado M, Gomez Bañuelos E, Ruiz Quezada S, Castro Albarrán J, Sánchez López L, et al. The Impact of LEP G-2548A and LEPR Gln223Arg Polymorphisms on Adiposity, Leptin, and Leptin-Receptor Serum Levels in a Mexican Mestizo Population. Biomed Res Int. 2015;2015:539408 pubmed publisher
Derosa G, Querci F, Franzetti I, Dario Ragonesi P, D Angelo A, Maffioli P. Comparison of the effects of barnidipine+losartan compared with telmisartan+hydrochlorothiazide on several parameters of insulin sensitivity in patients with hypertension and type 2 diabetes mellitus. Hypertens Res. 2015;38:690-4 pubmed publisher
Tellechea M, Gianotti T, Alvariñas J, González C, Sookoian S, Pirola C. Telomere length in the two extremes of abnormal fetal growth and the programming effect of maternal arterial hypertension. Sci Rep. 2015;5:7869 pubmed publisher
Joshi R, Kim W, Lee S. Association between obesity-related adipokines and colorectal cancer: a case-control study and meta-analysis. World J Gastroenterol. 2014;20:7941-9 pubmed publisher
Ma Y, Liu Z, Zhang Y, Lu B. Serum leptin, adiponectin and endometrial cancer risk in Chinese women. J Gynecol Oncol. 2013;24:336-41 pubmed publisher
Ojeda I, Moreno Guzmán M, González Cortés A, Yáñez Sedeño P, Pingarron J. A disposable electrochemical immunosensor for the determination of leptin in serum and breast milk. Analyst. 2013;138:4284-91 pubmed publisher
Derosa G, Fogari E, D Angelo A, Bianchi L, Bonaventura A, Romano D, et al. Adipocytokine levels in obese and non-obese subjects: an observational study. Inflammation. 2013;36:914-20 pubmed publisher
Kim E, An S, Lee M, Kim T, Lee H, Hwang W, et al. Fermented kimchi reduces body weight and improves metabolic parameters in overweight and obese patients. Nutr Res. 2011;31:436-43 pubmed publisher
Lin Y, Ho Y, Lee J, Huang H, Huang K, Chen M. Plasma leptin levels and digital pulse volume in obese patients without metabolic syndrome--a pilot study. Clin Chim Acta. 2011;412:730-4 pubmed publisher
product information
Product ID :
ADI-900-028A
Catalog Number :
ADI-900-028A
Product Name :
Leptin (human), ELISA kit
Product Type :
Kit
Size :
96 wells
list of Pubmed id :
26064921, 25994603, 25598199, 24976730, 24167669, 23662299, 23467997, 21745625, 21195702
Product Description :
The Leptin (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours.
SPECIES REACTIVITY :
Human
Background :
The adipokine leptin is a hormone secreted predominantly by adipose tissue that signals through leptin receptors in the hypothalamus to decrease appetite and increase energy expenditure. Binding of leptin to the long-form of the leptin receptor in the hypothalamus reduces neuropeptide Y (NPY) and agouti-related protein (AgRP) activity, while stimulating anorexigenic pro-opiomelanocortin (POMC) neuron activity to reduce appetite. In peripheral tissues, leptin antagonizes insulin signaling, increases fatty acid oxidation, decreases insulin production in pancreatic beta cells, and promotes fertility. Its expression in adipocytes can be regulated in a paracrine fashion by other adipokines such as IL-6 (stimulation) and TNF-α (inhibition). Leptin deficient mice display severe insulin resistance, obesity, and decreased fertility, all of which are reversible by administration of exogenous leptin. In contrast, elevated circulating levels of leptin are associated with increased obesity, indicative of an acclimated state of leptin resistance which is not well understood.
ALTnames :
OB gene product
Uses :
For the quantitative determination of human leptin in culture supernatants, plasma, and serum.
Application Summary :
ELISA, Colorimetric detection
Storage :
+4°C
company information
Enzo Life Sciences
5777 Hines Drive
Ann Arbor, MI 48108
info-us@enzolifesciences.
https://www.enzolifesciences.com
1-800-942-0430
headquarters: USA
Enzo Life Sciences, incorporating ALEXIS® Biochemicals and BIOMOL® International, offers a comprehensive panel of innovative life science reagents. Antibodies, enzymes, proteins, small molecule inhibitors, product libraries, and assay kits are available for research in Cancer, Cell Death, Epigenetics, Genomics, Immunology, Neuroscience, Signal Transduction, and Ubiquitin & Proteasomes, Enabling Discovery in Life Science(tm). Visit www.enzolifesciences.com.