Big Endothelin-1 (human), ELISA kit | Enzo Life Sciences ADI-900-022 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Big Endothelin-1 (human), ELISA kit

catalog :

ADI-900-022

quantity :

96 wells

citations: 2

Reference
Zagariya A, Doherty J, Bhat R, Navale S, McMillen M, Uhal B, et al. Elevated immunoreactive endothelin-1 levels in newborn rabbit lungs after meconium aspiration. Pediatr Crit Care Med. 2002;3:297-302 pubmed
Woods M, Mitchell J, Wood E, Barker S, Walcot N, Rees G, et al. Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme. Mol Pharmacol. 1999;55:902-9 pubmed

product information

Product ID :

ADI-900-022

Catalog Number :

ADI-900-022

Product Name :

Big Endothelin-1 (human), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

12780972, 10220569

Product Description :

The Big Endothelin-1 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results overnight + 1 hour.

SPECIES REACTIVITY :

Human

Background :

Endothelins (ET) are isopeptides produced by vascular endothelium that have potent vasoconstrictive activity. The peptides are encoded by three separate genes and processed to yield 39-residue "Big ET" molecules which are further processed to the 21 amino acid sequences designated ET-1, ET-2 and ET-3. ET action is mediated via binding to two receptors, ETA and ETB. Activation of ETA increases vasoconstriction and sodium retention, thereby increasing blood pressure. Activation of ETB receptors triggers the release of vasorelaxive factors such as nitric oxide (NO) and prostanoids from endothelial cells and increases urine production and elimination, thereby lowering blood pressure.

ALTnames :

Big ET-1

Uses :

For the quantitative determination of human Big ET-1 in culture supernatants and serum. Cited species and sample type include rabbit and lung lavage fluid (ref. 1).

Application Summary :

ELISA, Colorimetric detection

Storage :

+4°C