Leptin (rat), ELISA kit | Enzo Life Sciences ADI-900-015A product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Enzo Life Sciences

other brands :

Stressgen, BioMol, Alexis Corporation, Assay Designs, Alexis

product type :

ELISA/assay

product name :

Leptin (rat), ELISA kit

catalog :

ADI-900-015A

quantity :

96 wells

citations: 12

Reference
Mantanona C, Alsiö J, Elson J, Fisher B, Dalley J, Bussey T, et al. Altered motor, anxiety-related and attentional task performance at baseline associate with multiple gene copies of the vesicular acetylcholine transporter and related protein overexpression in ChAT::Cre+ rats. Brain Struct Funct. 2019;: pubmed publisher
Mukherjee R, Yun J. Lactobionic acid reduces body weight gain in diet-induced obese rats by targeted inhibition of galectin-1. Biochem Biophys Res Commun. 2015;463:1311-6 pubmed publisher
Li S, Liao X, Meng F, Wang Y, Sun Z, Guo F, et al. Therapeutic role of ursolic acid on ameliorating hepatic steatosis and improving metabolic disorders in high-fat diet-induced non-alcoholic fatty liver disease rats. PLoS ONE. 2014;9:e86724 pubmed publisher
Ge J, Qi C, Zhou J. Imbalance of leptin pathway and hypothalamus synaptic plasticity markers are associated with stress-induced depression in rats. Behav Brain Res. 2013;249:38-43 pubmed publisher
Choi M, Choi J, Chaudhari H, Aseer K, Mukherjee R, Yun J. Gender-dimorphic regulation of skeletal muscle proteins in streptozotocin-induced diabetic rats. Cell Physiol Biochem. 2013;31:408-20 pubmed publisher
Barazzoni R, Semolic A, Cattin M, Zanetti M, Guarnieri G. Acylated ghrelin limits fat accumulation and improves redox state and inflammation markers in the liver of high-fat-fed rats. Obesity (Silver Spring). 2014;22:170-7 pubmed publisher
Yim H, Ha K, Bae I, Yoo K, Hong Y, Lee J. Overweight, hypertension and renal dysfunction in adulthood of neonatally overfed rats. J Nutr Biochem. 2013;24:1324-33 pubmed publisher
Messenger S, Ciriello J. Effects of intermittent hypoxia on leptin signalling in the carotid body. Neuroscience. 2013;232:216-25 pubmed publisher
de Oliveira J, Lisboa P, de Moura E, Barella L, Miranda R, Malta A, et al. Poor pubertal protein nutrition disturbs glucose-induced insulin secretion process in pancreatic islets and programs rats in adulthood to increase fat accumulation. J Endocrinol. 2013;216:195-206 pubmed publisher
Gálvez Prieto B, Somoza B, Gil Ortega M, García Prieto C, de Las Heras A, Gonzalez M, et al. Anticontractile Effect of Perivascular Adipose Tissue and Leptin are Reduced in Hypertension. Front Pharmacol. 2012;3:103 pubmed publisher
Rajapurohitam V, Kilic A, Javadov S, Karmazyn M. Role of NF-?B and p38 MAPK activation in mediating angiotensin II and endothelin-1-induced stimulation in leptin production and cardiomyocyte hypertrophy. Mol Cell Biochem. 2012;366:287-97 pubmed publisher
Merino B, Cano V, Guzmán R, Somoza B, Ruiz Gayo M. Leptin-mediated hypothalamic pathway of cholecystokinin (CCK-8) to regulate body weight in free-feeding rats. Endocrinology. 2008;149:1994-2000 pubmed

product information

Product ID :

ADI-900-015A

Catalog Number :

ADI-900-015A

Product Name :

Leptin (rat), ELISA kit

Product Type :

Kit

Size :

96 wells

list of Pubmed id :

26116537, 24489777, 23619134, 23548559, 23512916, 23333086, 23151360, 22679436, 22527934, 18096657

Product Description :

The Leptin (rat), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours.

SPECIES REACTIVITY :

Rat

Background :

The adipokine leptin is a hormone secreted predominantly by adipose tissue that signals through leptin receptors in the hypothalamus to decrease appetite and increase energy expenditure. Binding of leptin to the long-form of the leptin receptor in the hypothalamus reduces neuropeptide Y (NPY) and agouti-related protein (AgRP) activity, while stimulating anorexigenic pro-opiomelanocortin (POMC) neuron activity to reduce appetite. In peripheral tissues, leptin antagonizes insulin signaling, increases fatty acid oxidation, decreases insulin production in pancreatic beta cells, and promotes fertility. Its expression in adipocytes can be regulated in a paracrine fashion by other adipokines such as IL-6 (stimulation) and TNF-α (inhibition). Leptin deficient mice display severe insulin resistance, obesity, and decreased fertility, all of which are reversible by administration of exogenous leptin. In contrast, elevated circulating levels of leptin are associated with increased obesity, indicative of an acclimated state of leptin resistance which is not well understood.

ALTnames :

OB gene product

Uses :

For the quantitative determination of rat leptin in culture supernatants, plasma, and serum.

Application Summary :

ELISA, Colorimetric detection

Storage :

+4°C