ELISA/assay

Secretory IgA (sIgA) ELISA

SGA35-K01

Secretory IgA (sIgA) ELISA

Secretory IgA is comprised of two immunoglobulin A molecules, which are joined by a J-protein and a secretory component. The secretory component is synthesized by epithelial cells of the mucous membrane of gastrointestinal, respiratory and urogenital tracts. Secretory IgA is also produced by the saliva, tear and mammary glands. The plasma cells in the subendothelial area of mucous membranes are releasing a complex of two IgA-molecules, which are joined over the J-protein. This complex is binding to a secretory component, located at the surface of the epithelial cell. After binding, the sIgA is transported across the cell and excreted by exocytosis. The determination of secretory IgA (sIgA) allows a first overview of the functionality of the gastrointestinal associated immune system (GALT). At this the secretory power and the degree of stimulation of the plasma cells of the intestinal submucosa is determined. The Eagle Biosciences Secretory IgA (sIgA) ELISA kit allows for an easy, rapid and precise quantitative determination of secretory IgA in biological samples. The kit includes all reagents ready to use for preparation of the samples.