ELISA/assay

Human Apolipoprotein AI and Apolipoprotein B Duplex ELISA Kit

ARG81205

Human Apolipoprotein AI and Apolipoprotein B Duplex ELISA Kit

Apolipoprotein AI (ApoAI) which is the major protein component of high density lipoprotein (HDL) in plasma. The protein promotes cholesterol efflux from tissues to the liver for excretion, and it is a cofactor for lecithin cholesterolacyltransferase (LCAT) which is responsible for the formation of most plasma cholesteryl esters. [provided by RefSeq, Jul 2008] Apolipoprotein B (ApoB) occurs in plasma as two main isoforms, apoB-48 and apoB-100: the former is synthesized exclusively in the gut and the latter in the liver. Apolipoprotein B is a major protein constituent of chylomicrons (apo B48), LDL (apo B-100) and VLDL (apo B-100). Apo B-100 functions as a recognition signal for the cellular binding and internalization of LDL particles by the apoB/E receptor. [provided by RefSeq, Jul 2008 and uniprot] ApoA1 is often used as a biomarker for prediction of cardiovascular diseases. The ratio apoB-100/apoA1 (i.e. LDL & larger particles vs. HDL particles), NMR measured Lipoprotein (LDL/HDL) particle ratios has always had a stronger correlation with myocardial infarction event rates than older methods of measuring lipid transport in the water outside cells. [provided by wikipedia] A recent study indicated that determining the ratio of ApoB to ApoAI is the best predictor of those at risk of heart attack.