product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
Aquaporin 4
catalog :
ab3594
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 27
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; 1:400; loading ...; fig 3b
  • immunohistochemistry - paraffin section; mouse; 1:400; loading ...; fig 3a
  • western blot; mouse; 1:1000; loading ...; fig 3e
Zhang R, Liu Y, Chen Y, Li Q, Marshall C, Wu T, et al. Aquaporin 4 deletion exacerbates brain impairments in a mouse model of chronic sleep disruption. CNS Neurosci Ther. 2020;26:228-239 pubmed publisher
  • immunohistochemistry; mouse; 1:500; loading ...; fig 7a
  • western blot; mouse; 1:500; loading ...; fig 7b
Gautam J, Zhang X, Yao Y. The role of pericytic laminin in blood brain barrier integrity maintenance. Sci Rep. 2016;6:36450 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig 5
Körbelin J, Dogbevia G, Michelfelder S, Ridder D, Hunger A, Wenzel J, et al. A brain microvasculature endothelial cell-specific viral vector with the potential to treat neurovascular and neurological diseases. EMBO Mol Med. 2016;8:609-25 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 3
Beaudet M, Yang Q, Cadau S, Blais M, Bellenfant S, Gros Louis F, et al. High yield extraction of pure spinal motor neurons, astrocytes and microglia from single embryo and adult mouse spinal cord. Sci Rep. 2015;5:16763 pubmed publisher
  • immunohistochemistry; rat; fig 4
  • western blot; rat; fig 6
  • immunohistochemistry; human; fig 1
Stokum J, Mehta R, Ivanova S, Yu E, Gerzanich V, Simard J. Heterogeneity of aquaporin-4 localization and expression after focal cerebral ischemia underlies differences in white versus grey matter swelling. Acta Neuropathol Commun. 2015;3:61 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:250; fig 4
Cases O, Joseph A, Obry A, Santin M, Ben Yacoub S, Pâques M, et al. Foxg1-Cre Mediated Lrp2 Inactivation in the Developing Mouse Neural Retina, Ciliary and Retinal Pigment Epithelia Models Congenital High Myopia. PLoS ONE. 2015;10:e0129518 pubmed publisher
Nirwane A, Johnson J, Nguyen B, Miner J, Yao Y. Mural cell-derived laminin-α5 plays a detrimental role in ischemic stroke. Acta Neuropathol Commun. 2019;7:23 pubmed publisher
Mestre H, Hablitz L, Xavier A, Feng W, Zou W, Pu T, et al. Aquaporin-4-dependent glymphatic solute transport in the rodent brain. elife. 2018;7: pubmed publisher
von Holstein Rathlou S, Petersen N, Nedergaard M. Voluntary running enhances glymphatic influx in awake behaving, young mice. Neurosci Lett. 2018;662:253-258 pubmed publisher
Stokum J, Kwon M, Woo S, Tsymbalyuk O, Vennekens R, Gerzanich V, et al. SUR1-TRPM4 and AQP4 form a heteromultimeric complex that amplifies ion/water osmotic coupling and drives astrocyte swelling. Glia. 2018;66:108-125 pubmed publisher
Suzuki T, Seki S, Hiramoto K, Naganuma E, Kobayashi E, Yamaoka A, et al. Hyperactivation of Nrf2 in early tubular development induces nephrogenic diabetes insipidus. Nat Commun. 2017;8:14577 pubmed publisher
Onoda A, Takeda K, Umezawa M. Dose-dependent induction of astrocyte activation and reactive astrogliosis in mouse brain following maternal exposure to carbon black nanoparticle. Part Fibre Toxicol. 2017;14:4 pubmed publisher
Ma S, Jiang B, Deng W, Gu Z, Wu F, Li T, et al. D-2-hydroxyglutarate is essential for maintaining oncogenic property of mutant IDH-containing cancer cells but dispensable for cell growth. Oncotarget. 2015;6:8606-20 pubmed
Chen C, Koche R, Sinha A, Deshpande A, Zhu N, Eng R, et al. DOT1L inhibits SIRT1-mediated epigenetic silencing to maintain leukemic gene expression in MLL-rearranged leukemia. Nat Med. 2015;21:335-43 pubmed publisher
Anderova M, Benesova J, Mikešová M, Dzamba D, Honsa P, Kriška J, et al. Altered astrocytic swelling in the cortex of α-syntrophin-negative GFAP/EGFP mice. PLoS ONE. 2014;9:e113444 pubmed publisher
Luense S, Denner P, Fernández Montalván A, Hartung I, Husemann M, Stresemann C, et al. Quantification of histone H3 Lys27 trimethylation (H3K27me3) by high-throughput microscopy enables cellular large-scale screening for small-molecule EZH2 inhibitors. J Biomol Screen. 2015;20:190-201 pubmed publisher
Fl gge G, Araya Callis C, Garea Rodríguez E, Stadelmann Nessler C, Fuchs E. NDRG2 as a marker protein for brain astrocytes. Cell Tissue Res. 2014;357:31-41 pubmed publisher
van der Linden M, Willekes M, van Roon E, Seslija L, Schneider P, Pieters R, et al. MLL fusion-driven activation of CDK6 potentiates proliferation in MLL-rearranged infant ALL. Cell Cycle. 2014;13:834-44 pubmed publisher
Yao Y, Chen Z, Norris E, Strickland S. Astrocytic laminin regulates pericyte differentiation and maintains blood brain barrier integrity. Nat Commun. 2014;5:3413 pubmed publisher
Ding T, Zhou Y, Sun K, Jiang W, Li W, Liu X, et al. Knockdown a water channel protein, aquaporin-4, induced glioblastoma cell apoptosis. PLoS ONE. 2013;8:e66751 pubmed publisher
Lai Z, Moravcová S, Canitrot Y, Andrzejewski L, Walshe D, Rea S. Msl2 is a novel component of the vertebrate DNA damage response. PLoS ONE. 2013;8:e68549 pubmed publisher
Fu H, Maunakea A, Martin M, Huang L, Zhang Y, Ryan M, et al. Methylation of histone H3 on lysine 79 associates with a group of replication origins and helps limit DNA replication once per cell cycle. PLoS Genet. 2013;9:e1003542 pubmed publisher
Ulanovskaya O, Zuhl A, Cravatt B. NNMT promotes epigenetic remodeling in cancer by creating a metabolic methylation sink. Nat Chem Biol. 2013;9:300-6 pubmed publisher
Bjørnstad L, Meza T, Otterlei M, Olafsrud S, Meza Zepeda L, Falnes P. Human ALKBH4 interacts with proteins associated with transcription. PLoS ONE. 2012;7:e49045 pubmed publisher
Ma M, Heath C, Hair A, West A. Histone crosstalk directed by H2B ubiquitination is required for chromatin boundary integrity. PLoS Genet. 2011;7:e1002175 pubmed publisher
Li S, Yang D, Yeung C, Yu W, Chang R, So K, et al. Lycium barbarum polysaccharides reduce neuronal damage, blood-retinal barrier disruption and oxidative stress in retinal ischemia/reperfusion injury. PLoS ONE. 2011;6:e16380 pubmed publisher
Goodyear M, Junghans B, Giummarra L, Murphy M, Crewther D, Crewther S. A role for aquaporin-4 during induction of form deprivation myopia in chick. Mol Vis. 2008;14:298-307 pubmed
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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