PGC-1alpha Mouse mAb (4C1.3) | EMD Millipore ST1202-1SET product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PGC-1alpha Mouse mAb (4C1.3)

catalog :

ST1202-1SET

quantity :

1 set

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, proximity ligation assay, western blot knockout validation

citations: 8

Published Application/Species/Sample/Dilution	Reference
western blot knockout validation; mouse; fig 1	Jiang H, Kang S, Zhang S, Karuppagounder S, Xu J, Lee Y, et al. Adult Conditional Knockout of PGC-1? Leads to Loss of Dopamine Neurons. Eneuro. 2016;3: pubmed publisher
western blot; mouse; loading ...; fig 5h	Kuang Z, Wang Y, Li Y, Ye C, Ruhn K, Behrendt C, et al. The intestinal microbiota programs diurnal rhythms in host metabolism through histone deacetylase 3. Science. 2019;365:1428-1434 pubmed publisher
western blot; mouse; fig s2p	Das A, Huang G, Bonkowski M, Longchamp A, Li C, Schultz M, et al. Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging. Cell. 2018;173:74-89.e20 pubmed publisher
western blot; mouse; 1:2000; loading ...; fig 4b	Nagar S, Trudler D, McKercher S, PiÃ±a Crespo J, Nakanishi N, Okamoto S, et al. Molecular Pathway to Protection From Age-Dependent Photoreceptor Degeneration in Mef2 Deficiency. Invest Ophthalmol Vis Sci. 2017;58:3741-3749 pubmed publisher
western blot; mouse; loading ...; fig s4g	Emmett M, Lim H, Jager J, Richter H, Adlanmerini M, Peed L, et al. Histone deacetylase 3 prepares brown adipose tissue for acute thermogenic challenge. Nature. 2017;546:544-548 pubmed publisher
proximity ligation assay; mouse; fig 2f western blot; mouse; fig 2a	Gallardo Montejano V, Saxena G, Kusminski C, Yang C, McAfee J, Hahner L, et al. Nuclear Perilipin 5 integrates lipid droplet lipolysis with PGC-1?/SIRT1-dependent transcriptional regulation of mitochondrial function. Nat Commun. 2016;7:12723 pubmed publisher
western blot; human; 1 ug/ml; fig 1	Roggia M, Ueta T. Î±vÎ²5 Integrin/FAK/PGC-1Î± Pathway Confers Protective Effects on Retinal Pigment Epithelium. PLoS ONE. 2015;10:e0134870 pubmed publisher
western blot; mouse; fig 5	Xu R, Hu Q, Ma Q, Liu C, Wang G. The protease Omi regulates mitochondrial biogenesis through the GSK3Î²/PGC-1Î± pathway. Cell Death Dis. 2014;5:e1373 pubmed publisher

product information

Catalog Number :

ST1202-1SET

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-PGC-1alpha Mouse mAb (4C1.3)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

10891 (Hu), 19017 (Ms), 83516 (Rt)

Host Name :

Clone :

4C1.3

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-PGC-1alpha Mouse mAb (4C1.3)

Cross Reactivity :

Human, Mouse, Rat

Background :

PGC-1alpha is a co-activator of PPARalpha, PPARɣ, and other transcription factors and regulates the transcriptonal program of adaptive thermogenesis in brown adipose tissue, hepatic/renal gluconeogenesis, and muscle fiber type switching. The full-length protein is 113 kDa and is induced in brown adipose tissue by cold exposure, in liver and kidney by fasting, and in skeletal muscle by exercise. Alternative splicing of the full-length gene produces a 270 aa N-terminal splice variant that migrates at ~38 kDa and is induced by the same physiological signals that induce expression of the full-length protein. The N-terminal PGC-1alpha splice variant is also subject to post translational modifications that alter its migration and apparent molecular weight.

ALT Names :

A830037N07RIK, LEM6, PGC-1, PGC-1(alpha), Pgc-1alpha-a, PGC-1v, PGC1 ALPHA, PGC1A, PGCO1, PPARGC-1 alpha, PPARGC1, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

Immunogen :

a recombinant protein consisting of amino acids 1-120 of mouse PGC-1alpha

Specificity :

Recognizes the endogenous forms of PGC-1alpha, which includes the ~113 kDa PGC-1alpha protein and the ~38 kDa splice variant.

Package Size :

1 set

Uses :

WB, IC, IP

Storage :

Following initial thaw, aliquot and freeze (-70°C). Avoid repeated freeze-thaw.