Tiam1 Rabbit pAb | EMD Millipore ST1070-50UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Tiam1 Rabbit pAb

catalog :

ST1070-50UG

quantity :

50 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

ST1070-50UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Tiam1 Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

7074 (Hu), 21844 (Ms), 304109 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-Tiam1 Rabbit pAb

Cross Reactivity :

Human, Mouse

Background :

Tiam1 (T-cell lymphoma invasion and metastasis 1) was originally identified by its ability to induce invasion by T-lymphoma cells when amplified. Tiam1 is a specific guanine nucleotide exchange factor (GEF) for the GTPase, Rac. By activating Rac1, Tiam1 regulates many cellular functions including actin cytoskeleton dynamics, cell proliferation, and cell survival. Tiam1 activity is regulated by its translocation to the membrane and the subsequent binding of its PH domain to phosphatidylinositol-3,4,5-triphosphate. Tiam1 is cleaved in a caspase-dependent manner in apoptotic cells, rendering it inactive as a result of an inability to translocate to the plasma membrane.

ALT Names :

AI847750, D16Ium10, D16Ium10e, FLJ36302, TIAM, T-cell lymphoma invasion and metastasis 1

Immunogen :

a synthetic peptide corresponding to amino acids from the C-terminal domain of human Tiam1

Specificity :

Recognizes the ~200 kDa Tiam1 protein.

Package Size :

50 ug

Uses :

Storage :

Following initial use, aliquot and freeze (-20°C) for long-term storage. Avoid freeze/thaw cycles.