PhosphoDetect™ Anti-JNK1/2 (pThr183/Tyr185) Rabbit pAb | EMD Millipore PS1019-100UL product information

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product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PhosphoDetect™ Anti-JNK1/2 (pThr183/Tyr185) Rabbit pAb

catalog :

PS1019-100UL

quantity :

100 uL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

western blot

product information

Catalog Number :

PS1019-100UL

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

PhosphoDetect™ Anti-JNK1/2 (pThr183/Tyr185) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

5599 (Hu), 26419 26420 (Ms), 116554 50658 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

PhosphoDetect™ Anti-JNK1/2 (pThr183/Tyr185) Rabbit pAb

Cross Reactivity :

Human, Mouse, Rat

Background :

c-Jun N-terminal Kinase (JNK) is a Stress Activated Protein Kinase/MAP Kinase (SAPK/MAPK) that exists as three isoforms, JNK1 (~49 kDa), JNK2 (~55 kDa), and JNK3 (~54 kDa). JNK is activated as a result of phosphorylation on Thr183 and Tyr185 by MEK4 and MEK7. JNK1 and JNK2 are expressed by numerous cells and tissues, while JNK3 is primarily expressed in neuronal cells. The JNK pathway, along with the p38 pathway, functions to modulate cell cycle, apoptotic, and transcriptional responses to stress.

ALT Names :

C-JUN N-TERMINAL KINASE1, JNK, JNK1, JNK1 PROTEIN KINASE, JNK1A2, JNK21B1/2, Sapk gamma, SAPK P46, SAPK1, SAPK1/JNK, STRESS-ACTIVATED PROTEIN KINASE-LIKE KINASE, Jnk p54, Jnk p55, JNK-55, JUNKINASE, p54a, PRKM9, SAPK, SAPK ALPHA, SAPK ALPHA 1, mitogen-activated protein kinase 8

Immunogen :

a synthetic phosphopeptide corresponding to amino acids surrounding the Thr 183 and Tyr 185 phosphorylation sites of human JNK1 and JNK2

Specificity :

Recognizes the ~49 kDa JNK1 and the ~55 kDa JNK2 proteins phosphorylated at Thr 183 and Tyr 185 .

Package Size :

100 uL

Uses :

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.