PhosphoDetect™ Anti-VEGFR 1 (Ab-2) (pTyr1213) Rabbit pAb | EMD Millipore PC459-25UL product information

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product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

PhosphoDetect™ Anti-VEGFR 1 (Ab-2) (pTyr1213) Rabbit pAb

catalog :

PC459-25UL

quantity :

25 uL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

antigen modification :

phosphorylated

reactivity :

human, mouse, rat

application :

immunohistochemistry

product information

Catalog Number :

PC459-25UL

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

PhosphoDetect™ Anti-VEGFR 1 (Ab-2) (pTyr1213) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

2321 (Hu), 14254 (Ms), 54251 (Rt)

Host Name :

Conjugate :

Undiluted Serum

Isotype :

IgG

Product Description :

PhosphoDetect™ Anti-VEGFR 1 (Ab-2) (pTyr1213) Rabbit pAb

Cross Reactivity :

Human

Background :

The vascular endothelial growth factor receptor-1 (VEGFR-1, approximately 180 kDa) protein is a member of a subfamily of receptor-tyrosine kinases characterized by the presence of seven immunoglobulin-like domains in the extracellular portion of the molecules and a split tyrosine-kinase domain intracellularly. Also known as Flt-1, VEGFR-1 is expressed primarily in endothelial cells but has also been demonstrated in various tumor cells, trophoblast cells, monocytes, and mesangial cells. The receptor is a glycoprotein but glycosylation is not required for activity. Following ligand binding VEGFR-1 undergoes autophosphorylation with the major sites being Tyr-1213 and Tyr-1333. Phosphorylation of Tyr-1213 in turn allows the binding of Nck, SHP-2 and P13K to the VEGFR-1 protein and subsequent signal transduction cascades initiated.

ALT Names :

AI323757, FLT, sFlt1, VEGFR-1, fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)

Immunogen :

a synthetic phosphopeptide [SDDVRpYVNAFK(C)] corresponding to amino acids 1208-1218 surrounding the Tyr 1213 phosphorylation site of human vascular endothelial growth factor receptor 1

Specificity :

Recognizes the ~180 kDa VEGFR-1 protein.

Package Size :

25 uL

Uses :

ELISA, IH(P)

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.