hMre-11 Rabbit pAb | EMD Millipore PC388-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

hMre-11 Rabbit pAb

catalog :

PC388-100UG

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 1	Termanis A, Torrea N, Culley J, Kerr A, Ramsahoye B, Stancheva I. The SNF2 family ATPase LSH promotes cell-autonomous de novo DNA methylation in somatic cells. Nucleic Acids Res. 2016;44:7592-604 pubmed publisher

product information

Catalog Number :

PC388-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-hMre-11 Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

4361 (Hu), 17535 (Ms), 64046 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-hMre-11 Rabbit pAb

Cross Reactivity :

Human, Mouse, Rat

Background :

Double strand breaks (DSB) in DNA are repaired by an evolutionarily conserved complex that includes the proteins Mre11 and Rad50. Both of these proteins are essential since nullizygous embryos die in utero, consistent with the fact that they both participate in two distinct processes: homologous recombination and non-homologous end joining. The Mre11 gene encodes a 680 amino acid protein that migrates on SDS/with an apparent mobility of ~85 kDa. Among many different functions ascribed to it, Mre11 exhibits a Mn2+-dependent 3'-5' exonuclease activity on double stranded DNA and a single-stranded endonuclease that facilitates repair of double strand breaks in DNA. Activation of Mre11 may involve post-translational modification since hyperphosphorylation is observed upon DNA damage. Efficient repair of DSBs in mammalian cells appears to require formation of nuclear foci comprised of Mre11, Rad50, and p95NBS1.

ALT Names :

ATLD, HNGS1, MRE11, MRE11B, MRE11 meiotic recombination 11 homolog A (S. cerevisiae)

Immunogen :

recombinant, human hMre11 protein

Specificity :

Recognizes the ~85 kDa hMre-11 protein.

Package Size :

100 ug

Uses :

WB, IF, IP

Storage :

Do not freeze