p53 (Ab-7) (Pantropic) Sheep pAb | EMD Millipore PC35-1EA product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p53 (Ab-7) (Pantropic) Sheep pAb

catalog :

PC35-1EA

quantity :

1 ea

clonality :

polyclonal

host :

domestic sheep

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; loading ...; fig s5a	Kim G, Rincon Fernandez Pacheco D, Saxon D, Yang A, Sabet S, Dutra Clarke M, et al. Rapid Generation of Somatic Mouse Mosaics with Locus-Specific, Stably Integrated Transgenic Elements. Cell. 2019;179:251-267.e24 pubmed publisher
chromatin immunoprecipitation; human; loading ...; fig 4a immunocytochemistry; human; loading ...; fig 3f western blot; human; loading ...; fig 1e	Garibaldi F, Falcone E, Trisciuoglio D, Colombo T, Lisek K, Walerych D, et al. Mutant p53 inhibits miRNA biogenesis by interfering with the microprocessor complex. Oncogene. 2016;35:3760-70 pubmed publisher

product information

Catalog Number :

PC35-1EA

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p53 (Ab-7) (Pantropic) Sheep pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

7157 (Hu), 22059 (Ms), 24842 (Rt)

Host Name :

Conjugate :

Undiluted Serum

Isotype :

IgG

Product Description :

Anti-p53 (Ab-7) (Pantropic) Sheep pAb

Cross Reactivity :

Human, Mouse, Rat

Background :

The human p53 tumor suppressor gene encodes a 393 amino acid phospho-protein that exhibits sequence-specific DNA binding and directly interacts with various cellular and viral proteins. p53 is the most commonly mutated gene in human cancer, with the majority of the mutations being amino acid substitutions. The normal function of p53 is to effect cell cycle arrest at the G1 and G2 checkpoints in response to DNA damage. This checkpoint function is executed by accumulation of p53 followed by induction of the GADD45, WAF1 and MDM2 genes. The current model of p53 function postulates that p53 senses DNA damage and arrests the cell cycle in either the G1 or G2 phases to allow DNA repair to take place. If repair is not successful, p53 initiates programmed cell death, thus preventing the propagation of genetic defects to successive generations of cells.

ALT Names :

bbl, bfy, bhy, Delta N p53, FLJ92943, LFS1, MGC112612, P53, Trp53, tumor protein p53

Immunogen :

recombinant, human p53 protein

Specificity :

Recognizes the ~53 kDa wild-type or mutant p53 protein.

Package Size :

1 ea

Uses :

IH, WB, IF, IP, IH(P)