GluR1 Rabbit pAb | EMD Millipore PC246-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

GluR1 Rabbit pAb

catalog :

PC246-100UG

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse; loading ...; fig s4a	Awasthi A, Ramachandran B, Ahmed S, Benito E, Shinoda Y, Nitzan N, et al. Synaptotagmin-3 drives AMPA receptor endocytosis, depression of synapse strength, and forgetting. Science. 2019;363: pubmed publisher
western blot; mouse; 1:1000; loading ...; fig 2e	Baglietto Vargas D, Prieto G, Limon A, Forner S, Rodriguez Ortiz C, Ikemura K, et al. Impaired AMPA signaling and cytoskeletal alterations induce early synaptic dysfunction in a mouse model of Alzheimer's disease. Aging Cell. 2018;17:e12791 pubmed publisher
immunocytochemistry; mouse; loading ...; fig 1g western blot; mouse; loading ...; fig 1h	Bodrikov V, Pauschert A, Kochlamazashvili G, Stuermer C. Reggie-1 and reggie-2 (flotillins) participate in Rab11a-dependent cargo trafficking, spine synapse formation and LTP-related AMPA receptor (GluA1) surface exposure in mouse hippocampal neurons. Exp Neurol. 2017;289:31-45 pubmed publisher
immunohistochemistry; mouse; loading ...; fig 4e	Park K, Ribic A, Laage Gaupp F, Coman D, Huang Y, Dulla C, et al. Excitatory Synaptic Drive and Feedforward Inhibition in the Hippocampal CA3 Circuit Are Regulated by SynCAM 1. J Neurosci. 2016;36:7464-75 pubmed publisher
immunocytochemistry; mouse; fig 5 western blot; mouse; fig 1	Ohashi R, Takao K, Miyakawa T, Shiina N. Comprehensive behavioral analysis of RNG105 (Caprin1) heterozygous mice: Reduced social interaction and attenuated response to novelty. Sci Rep. 2016;6:20775 pubmed publisher

product information

Catalog Number :

PC246-100UG

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-GluR1 Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

2890 (Hu), 14799 (Ms), 50592 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-GluR1 Rabbit pAb

Cross Reactivity :

Rat

Background :

Glutamate is the major excitatory neurotransmitter in the central nervous system. Precise regulation of glutamate levels are necessary as excess glutamate is toxic to neurons, presumably through receptor activation which leads to elevated intracellular Ca2+ levels. Multiple glutamate receptors have been identified in the mammalian brain, including the ligand-gated ion channels (ionotropic glutamate receptors) which are permeable to cations. These receptors have been classified into multiple subtypes based upon pharmacological and electrophysiological data, and includes the alpha-amino-3-hydroxy-5-methyl-4-isoxaxole propionate (AMPA)/kainate, and N-methyl-D-aspartate (NMDA) receptors. The ligand-gated glutamate receptors are multimeric heteromers composed of distinct subunits. Another subfamily of glutamate receptors includes eight G protein-coupled metabotropic glutamate receptors.

ALT Names :

Ampa1, GLR1, GLUH1, GLUR-A, GLUR1, HBGR1, HIPA1, MGC133252, glutamate receptor, ionotropic, AMPA 1

Immunogen :

a synthetic peptide (RTSDSRDHTRVDWKR) corresponding to amino acids 271-285 of rat GluR1 (numbered from the signal peptide)

Specificity :

Recognizes the ~105-107 kDa GluR1 protein.

Package Size :

100 ug

Uses :

WB, IF

Storage :

Do not freeze