Serotonin (5-HT) Transporter (602-622) Rabbit pAb | EMD Millipore PC177L-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Serotonin (5-HT) Transporter (602-622) Rabbit pAb

catalog :

PC177L-100UL

quantity :

100 uL

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - frozen section

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:5000; fig 2	Muzerelle A, Scotto Lomassese S, Bernard J, Soiza Reilly M, Gaspar P. Conditional anterograde tracing reveals distinct targeting of individual serotonin cell groups (B5-B9) to the forebrain and brainstem. Brain Struct Funct. 2016;221:535-61 pubmed publisher

product information

Catalog Number :

PC177L-100UL

Category :

Antibodies

Subcategory :

Neuroscience

Product Name :

Anti-Serotonin (5-HT) Transporter (602-622) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

6532 (Hu), 15567 (Ms), 25553 (Rt)

Host Name :

Conjugate :

Undiluted Serum

Isotype :

IgG

Product Description :

Anti-Serotonin (5-HT) Transporter (602-622) Rabbit pAb

Cross Reactivity :

Mouse, Rat

Background :

The serotonin (5-hydroxytryptamine; 5-HT) transporter (5-HTT) plays an important role in the re-uptake of serotonin from the nerve terminal to ultimately terminate the serotonin signal. The 5-HTT plays a critical role in the regulation of serotonin neurotransmission, which has been linked to mood and personality disorders, anxiety, eating disorders, and insomnia. The predicted 12 transmembrane serotonin transporter contains potential sites for phosphorylation and glycosylation. Because serotonin is involved in such a variety of biological processes, the 5-HTT has been a target for the development of antidepressants and psychostimulants. Blocking serotonin uptake at the synapse has been achieved using structurally related chemicals called Selective Serotonin Re-uptake Inhibitors (SSRI) which alleviate disorders such as depression and alcoholism. The 5-HTT is localized to the plasma membrane of neurons and glial cells, as well as blood platelets, placenta, and endothelial cells.

ALT Names :

5-HT TRANSPORTER, 5-HTT, 5-HTTLPR, AI323329, hSERT, HTT, MGC124313, MGC124314, OCD1, serotonin transporter, SERT, SOLUTE CARRIER FAMILY 6, MEMBER 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4

Immunogen :

a synthetic peptide corresponding to amino acids 602-622 of rat 5-HT transporter

Specificity :

Recognizes the serotonin (5-HT) transporter protein.

Package Size :

100 uL

Uses :

IH, WB, IF

Storage :

Reconstitute the lyophilized antibody with 100 ul of sterile distilled H 2 O. Reconstitute the entire contents of the vial; during shipment and handling portions of the lyophilized pellet may have become dislodged and may not be in the bottom of the vial. Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C. Further dilute with sterile PBS or Tris buffer to dilutions no higher than 1:10. Avoid repeated freeze-thaw.