NF-kappaB (p65, RelA) (Ab-2) Rabbit pAb | EMD Millipore PC138-100UL product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

NF-kappaB (p65, RelA) (Ab-2) Rabbit pAb

catalog :

PC138-100UL

quantity :

100 uL

clonality :

polyclonal

host :

rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunoprecipitation, EMSA

product information

Catalog Number :

PC138-100UL

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-NF-kappaB (p65, RelA) (Ab-2) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

5970 (Hu), 19697 (Ms), 309165 (Rt)

Host Name :

Conjugate :

Undiluted Serum

Isotype :

IgG

Product Description :

Anti-NF-kappaB (p65, RelA) (Ab-2) Rabbit pAb

Cross Reactivity :

Human

Background :

NFkappaB (Nuclear factor kappaB) is a transcription factor that plays crucial roles in gene regulation including those involved in immune and inflammatory responses. Active NFkappaB is most commonly composed of the heterodimer DNA binding subunits p50 and p65 (RelA). These subunits are members of a multigene family called the rel family. In addition to p50 and RelA, three other proteins are implicated in dimer formation leading to transcriptional activation, p52, c-rel and rel B. Inhibitors to this process exist including another member of the rel family IkappaBalpha which binds to c-rel, p65 and relB preventing DNA binding by their homo- or heterodimers. It has recently been shown that NFkappaB plays a role in the apoptotic process - when RelA, the gene that codes for an NFkappaB subunit, was knocked out, this lead to the death of mouse embryos through apoptosis of the liver cells.

ALT Names :

MGC131774, NF KAPPA B SUBUNIT P65, NF-kappaB, NFkB, NFKB P65, NFKB/P65, NFKB3, P65, p65 Nfkb, p65RelA, v-rel reticuloendotheliosis viral oncogene homolog A (avian)

Immunogen :

a synthetic peptide corresponding to amino acids near the N-terminal domain of human NF-kappaB p65 (RelA), conjugated to KLH

Specificity :

Recognizes the ~65 kDa NF-kappaB p65 (RelA) protein.

Package Size :

100 uL

Uses :

ELISA, EMSA, WB, IP

Storage :

Following initial thaw, aliquot and freeze (-20°C). Avoid repeated freeze-thaw.