ATM (Ab-3) (819-844) Rabbit pAb | EMD Millipore PC116-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

ATM (Ab-3) (819-844) Rabbit pAb

catalog :

PC116-100UG

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; fig 5	Ortega Atienza S, Wong V, Deloughery Z, Luczak M, Zhitkovich A. ATM and KAT5 safeguard replicating chromatin against formaldehyde damage. Nucleic Acids Res. 2016;44:198-209 pubmed publisher

product information

Catalog Number :

PC116-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-ATM (Ab-3) (819-844) Rabbit pAb

Product Type :

Antibodies

Clonality :

Polyclonal

Gene ID :

472 (Hu), 11920 (Ms), 300711 (Rt)

Host Name :

Conjugate :

Purified

Isotype :

IgG

Product Description :

Anti-ATM (Ab-3) (819-844) Rabbit pAb

Cross Reactivity :

Human

Background :

Ataxia telangiectasia (AT) is an autosomal recessive disease characterized by cerebellar degeneration, an uneven gait (ataxia), neuromotor deterioration, the appearance of dilated blood vessels (telangiectasia) in the conjunctiva of the eyes and skin, and a large increase in cancer susceptibility. Cells of AT patients have increased sensitivity to ionizing radiation, defects in G1 and G2 of the cell cycle, and are unable to effect a normal p53-dependent G1 arrest due to failure to properly induce WAF1. Identification of the gene in AT patients showed that the disease is caused by a mutation of a single gene called ATM. Cloning of the ATM cDNA indicates that it contains a large open reading frame and encodes a putative protein of 3056 amino acids. The C-terminal region has extensive homology to the catalytic domains of phosphatidylinositol 3-kinases (PI3 kinases).

ALT Names :

AI256621, AT1, ATA, Ataxia telangiectasia, ATC, ATD, ATDC, ATE, C030026E19RIK, DKFZp781A0353, MGC74674, TEL1, TELO1, ataxia telangiectasia mutated

Immunogen :

a synthetic peptide (CKSLASFIKKPFDRGEVESMEDDTNG) corresponding to amino acids 819-844 of human ATM

Specificity :

Recognizes the ~350 kDa ATM protein.

Package Size :

100 ug

Uses :

WB, IP

Storage :

Do not freeze