This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
EMD Millipore
other brands :
Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava
product type :
antibody
product name :
BRCA1
catalog :
OP92
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MS110

The same clone is also sold as:
reactivity :
human
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
citations: 23
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human; loading ...; fig 5c
  • western blot; human; fig 5a
Kim B, Jeong Y, Wong M, Martin L. DNA damage accumulates and responses are engaged in human ALS brain and spinal motor neurons and DNA repair is activatable in iPSC-derived motor neurons with SOD1 mutations. Acta Neuropathol Commun. 2020;8:7 pubmed publisher
  • western blot; human; 1:200; loading ...; fig 1b
Chiang H, Zhang X, Li J, Zhao X, Chen J, Wang H, et al. BRCA1-associated R-loop affects transcription and differentiation in breast luminal epithelial cells. Nucleic Acids Res. 2019;47:5086-5099 pubmed publisher
  • western blot; human; loading ...; fig s5b
Liu Y, Cussiol J, Dibitetto D, Sims J, Twayana S, Weiss R, et al. TOPBP1Dpb11 plays a conserved role in homologous recombination DNA repair through the coordinated recruitment of 53BP1Rad9. J Cell Biol. 2017;216:623-639 pubmed publisher
  • immunohistochemistry; human; loading ...; fig 4b
Spriggs C, Laimins L. FANCD2 Binds Human Papillomavirus Genomes and Associates with a Distinct Set of DNA Repair Proteins to Regulate Viral Replication. MBio. 2017;8: pubmed publisher
  • western blot; human; fig s2
Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig s2a
Korlimarla A, Prabhu J, Remacle J, Rajarajan S, Raja U, C E A, et al. Identification of BRCA1 Deficiency Using Multi-Analyte Estimation of BRCA1 and Its Repressors in FFPE Tumor Samples from Patients with Triple Negative Breast Cancer. PLoS ONE. 2016;11:e0153113 pubmed publisher
  • immunohistochemistry - paraffin section; human; 0.1 mg/ml; fig s1
Scalia C, Gendusa R, Cattoretti G. A 2-Step Laemmli and Antigen Retrieval Method Improves Immunodetection. Appl Immunohistochem Mol Morphol. 2016;24:436-46 pubmed publisher
  • western blot; human; fig 6
Butin Israeli V, Adam S, Jain N, Otte G, Neems D, Wiesmüller L, et al. Role of lamin b1 in chromatin instability. Mol Cell Biol. 2015;35:884-98 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Xu H, Xian J, Viré E, McKinney S, Wei V, Wong J, et al. Up-regulation of the interferon-related genes in BRCA2 knockout epithelial cells. J Pathol. 2014;234:386-97 pubmed publisher
Tokunaga E, Fujita A, Takizawa K, Baba K, Akiyoshi S, Nakamura Y, et al. CD44v9 as a poor prognostic factor of triple-negative breast cancer treated with neoadjuvant chemotherapy. Breast Cancer. 2019;26:47-57 pubmed publisher
Hodgson D, Dougherty B, Lai Z, Fielding A, Grinsted L, Spencer S, et al. Candidate biomarkers of PARP inhibitor sensitivity in ovarian cancer beyond the BRCA genes. Br J Cancer. 2018;119:1401-1409 pubmed publisher
Nacson J, Krais J, Bernhardy A, Clausen E, Feng W, Wang Y, et al. BRCA1 Mutation-Specific Responses to 53BP1 Loss-Induced Homologous Recombination and PARP Inhibitor Resistance. Cell Rep. 2018;24:3513-3527.e7 pubmed publisher
Seo A, Steinberg Shemer O, Unal S, Casadei S, Walsh T, Gumruk F, et al. Mechanism for survival of homozygous nonsense mutations in the tumor suppressor gene BRCA1. Proc Natl Acad Sci U S A. 2018;115:5241-5246 pubmed publisher
Daniels S, Burghel G, Chambers P, Al Baba S, Connley D, Brock I, et al. Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and "BRCA-Like" Status, in Both Blood and Tumour DNA. PLoS ONE. 2016;11:e0160174 pubmed publisher
Wang Y, Krais J, Bernhardy A, Nicolas E, Cai K, Harrell M, et al. RING domain-deficient BRCA1 promotes PARP inhibitor and platinum resistance. J Clin Invest. 2016;126:3145-57 pubmed publisher
Nagy Z, Kalousi A, Furst A, Koch M, Fischer B, Soutoglou E. Tankyrases Promote Homologous Recombination and Check Point Activation in Response to DSBs. PLoS Genet. 2016;12:e1005791 pubmed publisher
Fleury H, Communal L, Carmona E, Portelance L, Arcand S, Rahimi K, et al. Novel high-grade serous epithelial ovarian cancer cell lines that reflect the molecular diversity of both the sporadic and hereditary disease. Genes Cancer. 2015;6:378-398 pubmed
Santivasi W, Wang H, Wang T, Yang Q, Mo X, Brogi E, et al. Association between cytosolic expression of BRCA1 and metastatic risk in breast cancer. Br J Cancer. 2015;113:453-9 pubmed publisher
Goldstein M, Kastan M. Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res. 2015;75:2699-707 pubmed publisher
Gu Y, Bouwman P, Greco D, Saarela J, Yadav B, Jonkers J, et al. Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis. 2014;5:e1580 pubmed publisher
Pickholtz I, Saadyan S, Keshet G, Wang V, Cohen R, Bouwman P, et al. Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells. Oncotarget. 2014;5:11827-46 pubmed
Acharya S, Kaul Z, Gocha A, Martinez A, Harris J, Parvin J, et al. Association of BLM and BRCA1 during Telomere Maintenance in ALT Cells. PLoS ONE. 2014;9:e103819 pubmed publisher
Renaud E, Rosselli F. FANC pathway promotes UV-induced stalled replication forks recovery by acting both upstream and downstream Pol? and Rev1. PLoS ONE. 2013;8:e53693 pubmed publisher
company information
EMD Millipore
290 Concord Road
Billerica, Massachusetts 01821
bioscienceshelp@emdchemical.com
https://www.emdmillipore.com
888-854-3417
headquarters: United States
EMD Millipore is the Life Science division of Merck KGaA of Darmstadt, Germany

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