BRCA1 (Ab-1) Mouse mAb (MS110) | EMD Millipore OP92-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BRCA1 (Ab-1) Mouse mAb (MS110)

catalog :

OP92-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 2	Ahrabi S, Sarkar S, Pfister S, Pirovano G, Higgins G, Porter A, et al. A role for human homologous recombination factors in suppressing microhomology-mediated end joining. Nucleic Acids Res. 2016;44:5743-57 pubmed publisher
western blot; human; fig s3	Byrd P, Stewart G, Smith A, Eaton C, Taylor A, Guy C, et al. A Hypomorphic PALB2 Allele Gives Rise to an Unusual Form of FA-N Associated with Lymphoid Tumour Development. PLoS Genet. 2016;12:e1005945 pubmed publisher
chromatin immunoprecipitation; human; fig 1	Goldstein M, Kastan M. Repair versus Checkpoint Functions of BRCA1 Are Differentially Regulated by Site of Chromatin Binding. Cancer Res. 2015;75:2699-707 pubmed publisher
chromatin immunoprecipitation; human; fig 7 immunocytochemistry; human; fig 2 western blot; human; fig 1	Pickholtz I, Saadyan S, Keshet G, Wang V, Cohen R, Bouwman P, et al. Cooperation between BRCA1 and vitamin D is critical for histone acetylation of the p21waf1 promoter and growth inhibition of breast cancer cells and cancer stem-like cells. Oncotarget. 2014;5:11827-46 pubmed
immunocytochemistry; human; 1:100; fig 5 western blot; human; fig 4	Masaoka A, Gassman N, Horton J, Kedar P, Witt K, Hobbs C, et al. Interaction between DNA Polymerase ? and BRCA1. PLoS ONE. 2013;8:e66801 pubmed publisher

product information

Catalog Number :

OP92-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-BRCA1 (Ab-1) Mouse mAb (MS110)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

672 (Hu), 12189 (Ms), 497672 (Rt)

Host Name :

Clone :

MS110

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-BRCA1 (Ab-1) Mouse mAb (MS110)

Cross Reactivity :

Human

Background :

Inactivation of the BRCA1 gene, located at 17q21, is responsible for some forms of familial breast and ovarian cancer and sporadic ovarian cancer. BRCA1 encodes a protein of 1863 amino acids with an amino-terminal domain that exhibits similarity to the zinc-ring domain found in several regulatory and transcription factors. Mutations that disrupt this domain are some of the most frequently occurring ones linked to breast and ovarian cancer. Inhibition of BRCA1 expression leads to accelerated growth of mammary cells in vitro while loss of expression is observed during progression from benign disease to metastatic breast cancer suggesting that BRCA1 serves as a negative growth regulator. The ~220 kDa BRCA1 protein is expressed predominantly in the nucleus and appears to undergo cell cycle regulation with mRNA expression induced prior to DNA synthesis.

ALT Names :

BRCA1 (LACKING EXON 11), BRCAI, BRCC1, BROVCA1, IRIS, PSCP, RNF53, breast cancer 1, early onset

Immunogen :

recombinant human BRCA1

Specificity :

Recognizes the ~220 kDa BRCA1 protein.

Package Size :

100 ug

Uses :

IH, WB, IF, IP, IH(P)

Storage :

Do not freeze