p21WAF1 (Ab-3) Mouse mAb (DF10) | EMD Millipore OP68-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

p21WAF1 (Ab-3) Mouse mAb (DF10)

catalog :

OP68-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunoprecipitation

product information

Catalog Number :

OP68-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-p21WAF1 (Ab-3) Mouse mAb (DF10)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1026 (Hu), 12575 (Ms), 114851 (Rt)

Host Name :

Clone :

DF10

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-p21WAF1 (Ab-3) Mouse mAb (DF10)

Cross Reactivity :

Human

Background :

The tumor suppressor p53 transcriptionally activates a number of genes including the WAF1/CIP1 gene in response to DNA damage. The ~21 kDa product of the WAF1 gene is found in a complex involving cyclins, cyclin dependent kinases (CDK), and PCNA in normal cells but not transformed cells and appears to be a universal inhibitor of CDK activity. One consequence of p21WAF1 binding to and inhibiting CDKs is to prevent CDK-dependent phosphorylation and subsequent inactivation of the Rb protein which is essential for cell cycle progression. p21WAF1 is, therefore, a potent and reversible inhibitor of cell cycle progression at both the G1 and G2 checkpoints, presumably to allow sufficient time for DNA repair to be completed. Irreversible G1 or G2 arrest leads to apoptosis. However, the role of p21WAF1 in apoptosis is less clear although p53-mediated apoptosis leads to increased WAF1 expression.

ALT Names :

CAP20, CDKI, CDKN1, CDKNA1, CIP1, MDA-6, P21, p21/WAF1, P21CIP1, P21WAF, p21waf1, SDI1, WAF1, cyclin-dependent kinase inhibitor 1A (p21, Cip1)

Immunogen :

full-length, recombinant human p21 WAF1

Specificity :

Recognizes the ~21 kDa p21 WAF1 protein.

Package Size :

100 ug

Uses :

WB, IP

Storage :

Do not freeze