Bcl-2 (Ab-1) Mouse mAb (100) | EMD Millipore OP60-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Bcl-2 (Ab-1) Mouse mAb (100)

catalog :

OP60-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:2000; fig 1	Cerella C, Muller F, Gaigneaux A, Radogna F, Viry E, Chateauvieux S, et al. Early downregulation of Mcl-1 regulates apoptosis triggered by cardiac glycoside UNBS1450. Cell Death Dis. 2015;6:e1782 pubmed publisher

product information

Catalog Number :

OP60-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Bcl-2 (Ab-1) Mouse mAb (100)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

596 (Hu), 12043 (Ms), 24224 (Rt)

Host Name :

Clone :

100

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Bcl-2 (Ab-1) Mouse mAb (100)

Cross Reactivity :

Human

Background :

The bcl-2 proto-oncogene is encoded by a gene 230 kb in size that gives rise to a ~24-26 kDa protein which has been localized to the mitochondrial membrane. Although some data exists for implicating bcl-2 as a novel GTP binding protein, the major function of bcl-2 appears to be an inhibitor of apoptosis or ""programmed cell death"". It has now been well documented that bcl-2 becomes deregulated in tumor cells as a result of translocation into the immunoglobulin heavy-chain locus and is therefore constitutively activated in B cell malignancies (i.e. follicular lymphoma and chronic lymphocytic leukemia). In addition, bcl-2 has also been shown to protect mammalian cells from sodium azide, colchicine, DNA, RNA, and protein-synthesis inhibitors, as well as steroids, heat shock and irradiation.

ALT Names :

AW986256, Bcl2 alpha, C430015F12Rik, CED9, D630044D05RIK, D830018M01RIK, LOC100046608, ORF16, B-cell CLL/lymphoma 2

Immunogen :

a synthetic peptide (GAAPAPGIFSSQPG) corresponding to amino acids 41-54 of human Bcl-2

Specificity :

Recognizes the ~24-26 kDa bcl -2 protein.

Package Size :

100 ug

Uses :

IH, WB, IH(P)

Storage :

Do not freeze