DCC Mouse mAb (AF5) | EMD Millipore OP45-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

DCC Mouse mAb (AF5)

catalog :

OP45-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

Aplysia, human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation, blocking or activating experiments

citations: 2

Published Application/Species/Sample/Dilution	Reference
western blot; human	An X, Zhao Z, Luo Y, Zhang R, Tang X, Hao D, et al. Netrin-1 suppresses the MEK/ERK pathway and ITGB4 in pancreatic cancer. Oncotarget. 2016;7:24719-33 pubmed publisher
blocking or activating experiments; Aplysia; fig 8	Kim S, Martin K. Neuron-wide RNA transport combines with netrin-mediated local translation to spatially regulate the synaptic proteome. elife. 2015;4: pubmed publisher

product information

Catalog Number :

OP45-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-DCC Mouse mAb (AF5)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

1630 (Hu), 13176 (Ms), 25311 (Rt)

Host Name :

Clone :

AF5

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-DCC Mouse mAb (AF5)

Cross Reactivity :

Human

Background :

Invasive, metastatic colon cancer arises from pre-existing adenomas in both familial and sporadic cases and is characterized by the presence of multiple chromosomal alterations. In the progression from intramucosal carcinoma to invasive carcinoma, allelic loss on the long arm of chromosome 18 is frequently observed. Recently, a gene on 18q21.3 termed DCC, for deleted in colorectal carcinoma, has been isolated and shown to be deleted or mutated in both sporadic and inherited colon carcinoma whereas normal colonic tissue retained and expressed the gene. Furthermore, loss of DCC expression appears to accompany progression of adenomas to metastatic carcinoma. The inactivation of DCC suggests that it is a tumor suppressor gene. A functional role for DCC as a tumor suppressor gene is indicated by experiments demonstrating that introduction of a normal chromosome 18 into the human colon tumor cell lines COKFu or SW480.7 lacking DCC suppresses tumorigenicity.

ALT Names :

C030036D22RIK, Colorectal Ca+ supp, CRC18, CRCR1, Dcc1, IGDCC1, deleted in colorectal carcinoma

Immunogen :

the extracellular domain of human DCC

Specificity :

Recognizes the ~190 kDa DCC protein.

Package Size :

100 ug

Uses :

WB, IF, IP

Storage :

Do not freeze