APC (Ab-1) Mouse mAb (FE9) | EMD Millipore OP44-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

APC (Ab-1) Mouse mAb (FE9)

catalog :

OP44-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:500; loading ...; fig 4h, 5a, 5b	Ji L, Lu B, Wang Z, Yang Z, Reece Hoyes J, Russ C, et al. Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction. Mol Cell. 2018;72:37-47.e4 pubmed publisher
western blot; human; 1:1000; fig 3	Fotouhi O, Kjellin H, Larsson C, Hashemi J, Barriuso J, Juhlin C, et al. Proteomics Suggests a Role for APC-Survivin in Response to Somatostatin Analog Treatment of Neuroendocrine Tumors. J Clin Endocrinol Metab. 2016;101:3616-3627 pubmed
western blot; human; 1:100; fig 1 western blot; mouse; 1:100; fig 5	Mills K, Brocardo M, Henderson B. APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Mol Biol Cell. 2016;27:466-82 pubmed publisher

product information

Catalog Number :

OP44-100UG

Category :

Antibodies

Subcategory :

Epigenetics & Nuclear Function

Product Name :

Anti-APC (Ab-1) Mouse mAb (FE9)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

324 (Hu), 11789 (Ms), 24205 (Rt)

Host Name :

Clone :

FE9

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-APC (Ab-1) Mouse mAb (FE9)

Cross Reactivity :

Human, Mouse, Rat

Background :

Colon cancer generally occurs sporadically although there is clear genetic predisposition in some families. Familial Adenomatous Polyposis Coli (FAP) is an autosomal dominantly inherited disorder that exhibits 80 to 100% penetrance and predisposes to colon cancer. The gene responsible for FAP has been assigned to chromosome 5q21, a region that is often lost in tumors from patients with sporadic colorectal cancer. Recently, a gene called APC, for adenomatous polyposis coli, from the 5q21 locus was isolated and shown to contain mutations in DNA prepared from tumors of patients with sporadic colorectal cancer and in germ line DNA and tumor DNA from FAP patients. In 79 unrelated patients with FAP, mutations in APC were found in 67% of the cases; and 49 of the 53 mutations were either small deletions/insertion or were point mutations that introduced stop codons into the reading frame. Furthermore, APC mutations have been found in the earliest tumors that could be analyzed (0.

ALT Names :

AI047805, Apc7, AU020952, AW124434, BTPS2, DP2, DP2.5, DP3, Familial adenomatous polyposis, FAP, GS, Min, RATAPC, adenomatous polyposis coli

Immunogen :

a synthetic peptide corresponding to the N-terminal 35 amino acids of APC

Specificity :

Recognizes the ~300 kDa APC protein as well as a variety of truncated forms.

Package Size :

100 ug

Uses :

Storage :

Do not freeze