Pan-Ras (Ab-3) Mouse mAb (RAS 10) | EMD Millipore OP40-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Pan-Ras (Ab-3) Mouse mAb (RAS 10)

catalog :

OP40-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig 1	Dos Santos E, Carneiro Lobo T, Aoki M, Levantini E, BassÃ¨res D. Aurora kinase targeting in lung cancer reduces KRAS-induced transformation. Mol Cancer. 2016;15:12 pubmed publisher
western blot; human; 1:1000; fig 8	Slemmons K, Crose L, Rudzinski E, Bentley R, Linardic C. Role of the YAP Oncoprotein in Priming Ras-Driven Rhabdomyosarcoma. PLoS ONE. 2015;10:e0140781 pubmed publisher
western blot; human; fig 3	Ashford A, Dunkley T, Cockerill M, Rowlinson R, Baak L, Gallo R, et al. Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome. Cell Mol Life Sci. 2016;73:883-900 pubmed publisher

product information

Catalog Number :

OP40-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-Pan-Ras (Ab-3) Mouse mAb (RAS 10)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3845 (Hu), 16653 (Ms), 24525 (Rt)

Host Name :

Clone :

RAS 10

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-Pan-Ras (Ab-3) Mouse mAb (RAS 10)

Cross Reactivity :

Human, Mouse, Rat

Background :

The human ras gene family consists of three identified members H-, K- and N-ras encoding proteins of 188-189 amino acids and 21,000 (p21) daltons. Human H- and K-ras are the homologues of v-H- and v-K-ras, sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. Normal human cellular ras genes are referred to as proto-oncogenes, and have the potential for activation to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transforming ras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns of ras proto-oncogene proteins in normal human tissues are known, similar information for activated ras oncogene encoded p21s and their relevance to human disease diagnosis and prognosis is still emerging.

ALT Names :

C-K-RAS, c-Ki-ras, c-Ki-ras p21, Ha-ras, K-RAS B, K-RAS2A, K-RAS2B, K-RAS4A, KI-RAS, KI-RAS4B, KRAS1, KRAS2, MGC7141, NS, NS3, p21, p21B, p21ras, RAS, RAS1, RASH, RASK2, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Immunogen :

recombinant human p21 Ras

Specificity :

Recognizes the ~21 kDa Ras protein.

Package Size :

100 ug

Uses :

FC, IH, WB, IF, IP, IH(P)

Storage :

Do not freeze