c-K-Ras (Ab-1) Mouse mAb (234-4.2) | EMD Millipore OP24-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

c-K-Ras (Ab-1) Mouse mAb (234-4.2)

catalog :

OP24-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunoprecipitation

citations: 2

Published Application/Species/Sample/Dilution	Reference
immunoprecipitation; human; loading ...; tbl 1 western blot; human; fig 1d	Waters A, Ozkan Dagliyan I, Vaseva A, Fer N, Strathern L, Hobbs G, et al. Evaluation of the selectivity and sensitivity of isoform- and mutation-specific RAS antibodies. Sci Signal. 2017;10: pubmed publisher
western blot; human; loading ...; fig 6a	Lal S, Cheung E, Zarei M, Preet R, Chand S, Mambelli Lisboa N, et al. CRISPR Knockout of the HuR Gene Causes a Xenograft Lethal Phenotype. Mol Cancer Res. 2017;15:696-707 pubmed publisher

product information

Catalog Number :

OP24-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-c-K-Ras (Ab-1) Mouse mAb (234-4.2)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

3845 (Hu), 16653 (Ms), 24525 (Rt)

Host Name :

Clone :

234-4.2

Conjugate :

Purified

Isotype :

IgG2a

Product Description :

Anti-c-K-Ras (Ab-1) Mouse mAb (234-4.2)

Cross Reactivity :

Human, Mouse, Rat

Background :

The human ras gene family consists of three identified members, H, K and N-ras, encoding proteins of 188-189 amino acids and 21,000 (p21) molecular weight. Human H- and K-ras are the homologues of v-H- and v-K-ras sequences originally isolated from Harvey and Kirsten strains of rat sarcoma viruses. Normal human cellular ras genes can be activated to oncogenes by mutations occurring in codons 12, 13 and 61; such mutated, activated and transforming ras genes have been identified and isolated from human tumors and cultured tumor cells. Although the expression patterns of Ras proteins in normal human tissues are known, similar information for activated ras oncogene encoded p21s and their relevance to human disease diagnosis and prognosis is still emerging. K-ras mutations have been identified in several cancers to date including lung and colorectal tumors.

ALT Names :

C-K-RAS, c-Ki-ras, c-Ki-ras p21, Ha-ras, K-RAS B, K-RAS2A, K-RAS2B, K-RAS4A, KI-RAS, KI-RAS4B, KRAS1, KRAS2, MGC7141, NS, NS3, p21, p21B, p21ras, RAS, RAS1, RASH, RASK2, v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog

Immunogen :

recombinant, rat K-Ras

Specificity :

Recognizes the ~21 kDa c--KRas and v--KRas proteins. Also recognizes c-H-Ras and c-N-Ras.

Package Size :

100 ug

Uses :

IH, WB, IP, IH(P)

Storage :

Do not freeze