c-Abl (Ab-3) Mouse mAb (24-21) | EMD Millipore OP20-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

c-Abl (Ab-3) Mouse mAb (24-21)

catalog :

OP20-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunocytochemistry, immunoprecipitation

citations: 3

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; fig 4c	Chan L, Chen Z, Braas D, Lee J, Xiao G, Geng H, et al. Metabolic gatekeeper function of B-lymphoid transcription factors. Nature. 2017;542:479-483 pubmed publisher
western blot; human; fig 1a	Eiring A, Khorashad J, Anderson D, Yu F, Redwine H, Mason C, et al. Î²-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia. Leukemia. 2015;29:2328-37 pubmed publisher
western blot; human; fig 5	Modi H, Li L, Chu S, Rossi J, Yee J, Bhatia R. Inhibition of Grb2 expression demonstrates an important role in BCR-ABL-mediated MAPK activation and transformation of primary human hematopoietic cells. Leukemia. 2011;25:305-12 pubmed publisher

product information

Catalog Number :

OP20-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-c-Abl (Ab-3) Mouse mAb (24-21)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

25 (Hu), 11350 (Ms), 311860 (Rt)

Host Name :

Clone :

24-21

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-c-Abl (Ab-3) Mouse mAb (24-21)

Cross Reactivity :

Human, Mouse

Background :

The abl oncogene was initially identified as the viral transforming gene (v abl) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M MuLV). The v-abl genome consists of M-MuLV gag sequences fused to mouse c-abl, resulting in the production of phosphoproteins, p160 and p120 gag/c-abl with protein-tyrosine kinase activity, as the major translational products. The abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic (CML), 20-25% of adult acute lymphoblastic (ALL), and 2-5% of pediatric ALL. In these leukemias the c-abl proto-oncogene undergoes a chromosomal (9;22) translocation producing the Philadelphia (Ph1) chromosome resulting in the fusion of c-abl sequences to the bcr gene of chromosome 22. The molecular consequences of this translocation is the generation of a chimeric bcr/c-abl mRNA encoding activated abl protein-tyrosine kinase.

ALT Names :

ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl, c-abl oncogene 1, receptor tyrosine kinase

Immunogen :

a recombinant protein consisting of the carboxyl region of v-abl protein fused to TrpE

Specificity :

Recognizes the v-Abl, the ~145-150 kDa c-Abl, the ~210 kDa Bcr-Abl (CML), and the ~190 kDa Bcr-Abl (ALL) proteins.

Package Size :

100 ug

Uses :

WB, IF, IP

Storage :

Do not freeze