c-Abl (Ab-2) Mouse mAb (19-110) | EMD Millipore OP19-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

c-Abl (Ab-2) Mouse mAb (19-110)

catalog :

OP19-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, neutralization, immunoprecipitation

product information

Catalog Number :

OP19-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-c-Abl (Ab-2) Mouse mAb (19-110)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

25 (Hu), 11350 (Ms), 311860 (Rt)

Host Name :

Clone :

19-110

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-c-Abl (Ab-2) Mouse mAb (19-110)

Cross Reactivity :

Human, Mouse

Background :

The abl oncogene was initially identified as the viral transforming gene (v-abl) of Abelson murine leukemia virus (A-MuLV), from a chemically thymectomized mouse inoculated with Moloney murine leukemia virus (M-MuLV). The v-abl genome consists of M-MuLV gag sequences fused to mouse c-abl, resulting in the production of gag/c-abl tyrosine kinases, phosphoproteins p160 and p120, as the major translational products. The abl oncogene is implicated in several human leukemias including 90-95% of chronic myelocytic (CML), 20-25% of adult acute lymphoblastic (ALL) and 2-5% of pediatric ALL. In these leukemias the c-abl proto-oncogene undergoes a chromosomal translocation producing the Philadelphia (Ph1) chromosome resulting in the fusion of c-abl sequences to the bcr gene of chromosome 22. The molecular consequences of this translocation are the generation of a chimeric bcr/c-abl mRNA encoding activated abl protein-tyrosine kinase.

ALT Names :

ABL, AI325092, bcr/abl, C-ABL, C-ABL 1B, CABL1, E430008G22Rik, JTK7, MGC117749, p145Abl, p150, v-abl, c-abl oncogene 1, receptor tyrosine kinase

Immunogen :

a TrpE-v-Abl fusion protein

Specificity :

Recognizes the v-abl, CML c-brc/abl p210, human ALL c-brc/abl p190, human c-abl p145, and mouse c-abl p150 proteins.

Package Size :

100 ug

Uses :

WB, IP, NEUT

Storage :

Do not freeze