Noxa Mouse mAb (114C307) | EMD Millipore OP180-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

Noxa Mouse mAb (114C307)

catalog :

OP180-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot

citations: 5

Published Application/Species/Sample/Dilution	Reference
western blot; human; fig s3	Seo B, Min K, Woo S, Choe M, Choi K, Lee Y, et al. Inhibition of Cathepsin S Induces Mitochondrial ROS That Sensitizes TRAIL-Mediated Apoptosis Through p53-Mediated Downregulation of Bcl-2 and c-FLIP. Antioxid Redox Signal. 2017;27:215-233 pubmed publisher
western blot; human; 1:200; loading ...; fig s6d	Walerych D, Lisek K, Sommaggio R, Piazza S, Ciani Y, Dalla E, et al. Proteasome machinery is instrumental in a common gain-of-function program of the p53 missense mutants in cancer. Nat Cell Biol. 2016;18:897-909 pubmed publisher
western blot; human; fig 2	LaukovÃ¡ J, KozubÃk A, HofmanovÃ¡ J, NekvindovÃ¡ J, Sova P, Moyer M, et al. Loss of PTEN Facilitates Rosiglitazone-Mediated Enhancement of Platinum(IV) Complex LA-12-Induced Apoptosis in Colon Cancer Cells. PLoS ONE. 2015;10:e0141020 pubmed publisher
western blot; mouse; fig 9a	Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-Î²TrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
western blot; human; fig 7	Davis A, Qiao S, Lesson J, Rojo de la Vega M, Park S, Seanez C, et al. The quinone methide aurin is a heat shock response inducer that causes proteotoxic stress and Noxa-dependent apoptosis in malignant melanoma cells. J Biol Chem. 2015;290:1623-38 pubmed publisher

product information

Catalog Number :

OP180-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-Noxa Mouse mAb (114C307)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

5366 (Hu), 58801 (Ms), 492821 (Rt)

Host Name :

Clone :

114C307

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-Noxa Mouse mAb (114C307)

Cross Reactivity :

Human

Background :

Noxa, a BH3 member of the Bcl-2 family, has recently been identified in human and mouse. Expression of the Noxa gene involves direct activation of its promoter by p53. Increased expression of Noxa occurs in normal thymocytes, but does not occur in p53-deficient thymocytes. Coimmunoprecipitation data suggests that Noxa may interact with other members of the Bcl-2 family, including Bcl-XL and Mcl-1. Data has also shown that blocking the endogenous Noxa induction results in the suppression of apoptosis. Treating cells with Noxa antisense oligonucleotides blocks radiation-induced apoptosis, and this suggests that Noxa may be a mediator of p53-dependent apoptosis.

ALT Names :

APR, NOXA, phorbol-12-myristate-13-acetate-induced protein 1

Immunogen :

a recombinant protein consisting of human Noxa fused to GST

Specificity :

Recognizes the ~11 kDa Noxa protein.

Package Size :

100 ug

Uses :

Storage :

Following initial thaw, aliquot and freeze (-20°C;) Avoid repeated freeze-thaw.