c-ErbB3 (Ab-5) Mouse mAb (H3.105.5) | EMD Millipore OP120-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

c-ErbB3 (Ab-5) Mouse mAb (H3.105.5)

catalog :

OP120-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

immunocytochemistry, immunoprecipitation, flow cytometry

product information

Catalog Number :

OP120-100UG

Category :

Antibodies

Subcategory :

Cell Signaling

Product Name :

Anti-c-ErbB3 (Ab-5) Mouse mAb (H3.105.5)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

2065 (Hu), 13867 (Ms), 29496 (Rt)

Host Name :

Clone :

H3.105.5

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-c-ErbB3 (Ab-5) Mouse mAb (H3.105.5)

Cross Reactivity :

Human, Mouse

Background :

erbB3/HER3, a member of the epidermal growth factor receptor (EGF-R) family, was originally isolated as a cDNA clone from a human carcinoma cell line. The molecule is transcribed from a 6 kilobase mRNA, which can be identified in a variety of different tissues. Epidermal growth factor (EGF) initiates its effects on cell growth through interaction with a 170,000 dalton cell surface glycoprotein receptor. Binding of EGF, amphiregulin, or transforming growth factor-alpha (TGF alpha) to the receptor or to other members of the receptor family activates a tyrosine-specific protein kinase intrinsic to the EGF-receptor protein family. While there is a large degree of conserved homology between the cytoplasmic regions of EGF-R and HER2/neu, the HER3 molecule is more unique. This observation suggests that HER3 is subject to regulatory signals distinct from those affecting EGF-R and HER2/neu and, therefore, signals an alternate biochemical response.

ALT Names :

C-ERBB3, C76256, EGFR3, erbB3-S, ERBB3R, HER3, LCCS2, MDA-BF-1, MGC117742, MGC88033, p180-ErbB3, p45-sErbB3, p85-sErbB3, v-erb-b2 erythroblastic leukemia viral oncogene homolog 3 (avian)

Immunogen :

recombinant, human ErbB3 extracellular domain

Specificity :

Recognizes the ~185 kDa c-Erb B3/HER-3 protein.

Package Size :

100 ug

Uses :

FC, IF, IP

Storage :

For long-term storage, aliquot and freeze (-20°C). Avoid freeze/thaw cycles.