BRCA1 (Ab-4) Mouse mAb (SD118) | EMD Millipore OP107-100UG product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

EMD Millipore

other brands :

Oncogene Research Products, Calbiochem, Novagen, Merck, Upstate Biotechnology, Chemicon, LINCO, Novabiochem, Guava

product type :

antibody

product name :

BRCA1 (Ab-4) Mouse mAb (SD118)

catalog :

OP107-100UG

quantity :

100 ug

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation

citations: 1

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:200; loading ...; fig s1a	Bleuyard J, Fournier M, Nakato R, Couturier A, Katou Y, Ralf C, et al. MRG15-mediated tethering of PALB2 to unperturbed chromatin protects active genes from genotoxic stress. Proc Natl Acad Sci U S A. 2017;114:7671-7676 pubmed publisher

product information

Catalog Number :

OP107-100UG

Category :

Antibodies

Subcategory :

Apoptosis & Cancer

Product Name :

Anti-BRCA1 (Ab-4) Mouse mAb (SD118)

Product Type :

Antibodies

Clonality :

Monoclonal

Gene ID :

672 (Hu), 12189 (Ms), 497672 (Rt)

Host Name :

Clone :

SD118

Conjugate :

Purified

Isotype :

IgG1

Product Description :

Anti-BRCA1 (Ab-4) Mouse mAb (SD118)

Cross Reactivity :

Human

Background :

Inactivation of the BRCA1 gene is responsible for some forms of familial breast and ovarian cancer and sporadic ovarian cancer. BRCA1 encodes a protein of 1863 amino acids with an amino-terminal domain that exhibits similarity to the zinc-ring domain found in several regulatory and transcription factors. Two isoforms of BRCA1 are commonly expressed; a full length ~220 kDa protein that is predominantly nuclear and a ~120 kDa form that is missing most of exon 11. Inhibition of BRCA1 expression leads to accelerated growth of mammary cells in vitro while loss of expression is observed during progression from benign disease to metastatic breast cancer. BRCA1 undergoes cell cycle regulation, with mRNA expression induced prior to DNA synthesis, while DNA damage leads to down regulation.

ALT Names :

BRCA1 (LACKING EXON 11), BRCAI, BRCC1, BROVCA1, IRIS, PSCP, RNF53, breast cancer 1, early onset

Immunogen :

a recombinant polypeptide corresponding to amino acids 1005-1313 in exon 11 of human BRCA1

Specificity :

Recognizes the ~220 kDa BRCA1 protein.

Package Size :

100 ug

Uses :

IH, WB, IF, IP

Storage :

Do not freeze